In CA1 of young adult Wistar rats, endogenous VIP acting through VPAC1 receptor…

In CA1 of young adult Wistar rats, endogenous VIP acting through VPAC1 receptors (but not VPAC2) inhibits theta-burst-stimulation–induced LTP via GABAergic disinhibition, regulating CaMKII autophosphorylation and Kv4.2 channel phosphorylation.

{
  "n": null,
  "doi": "10.3390/biology11050627",
  "pmid": "35625355",
  "year": "2022",
  "claim": "In CA1 of young adult Wistar rats, endogenous VIP acting through VPAC1 receptors (but not VPAC2) inhibits theta-burst-stimulation–induced LTP via GABAergic disinhibition, regulating CaMKII autophosphorylation and Kv4.2 channel phosphorylation.",
  "pmcid": "PMC9138116",
  "title": "Endogenous VIP VPAC<sub>1</sub> Receptor Activation Modulates Hippocampal Theta Burst Induced LTP: Transduction Pathways and GABAergic Mechanisms.",
  "authors": "",
  "journal": "",
  "cite_key": "Caulinorocha2022",
  "evidence": "Hippocampal slice electrophysiology with VPAC1/VPAC2 selective antagonists; biochemical Western blot for CaMKII/GluA1/Kv4.2 phosphorylation.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "VPAC1 antagonism prevents VIP inhibition of TBS-LTP",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "young-adult Wistar rat CA1 hippocampal slices, theta-burst stimulation",
  "cited_by_count": 15,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 11,
  "claim_source_sentence": "Endogenous VIP, acting on VPAC1 (but not VPAC2) receptors, inhibited CA1 hippocampal LTP induced by TBS in young adult Wistar rats and this effect was dependent on GABAergic transmission and relied on the integrity of NMDA and CaMKII-dependent LTP expression mechanisms but not on PKA and PKC activity.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Endogenous VIP, acting on VPAC1 (but not VPAC2) receptors, inhibited CA1 hippocampal LTP induced by TBS in young adult Wistar rats"
}

[
  "paper:paper-42bc46b763d2"
]

Endogenous VIP, acting on VPAC1 (but not VPAC2) receptors, inhibited CA1 hippocampal LTP induced by TBS in young adult Wistar rats and this effect was dependent on GABAergic transmission and relied on the integrity of NMDA and CaMKII-dependent LTP expression mechanisms but not on PKA and PKC activity.

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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