Methodological limits and emerging tools

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Citation anchors captured: 135

Citation contexts

^{1Citationpaper:6f999156-d57b-49f0-a236-2c549c1190d6{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference} {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{2Citationpaper:272cb25f-50d5-4895-9bd2-9326ef951a25{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference} {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{3Citationpaper:paper-b6fa1f4bb5fd{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference} {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{4Citationpaper:paper-4d148ae6ffa9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference} {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{5Citationpaper:577e8d9c-6914-4e20-884c-e57013fb6564{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference} {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{6Citationpaper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference} {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{7Citationpaper:paper-89a449ba5293{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference} {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{8Citationpaper:paper-fa8bc7d8660d{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference} {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{9Citationpaper:paper-1c0b529903c9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference} {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{10Citationpaper:paper-07e278a78498{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference} {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{2Citationpaper:272cb25f-50d5-4895-9bd2-9326ef951a25{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}0 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{2Citationpaper:272cb25f-50d5-4895-9bd2-9326ef951a25{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}1 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{2Citationpaper:272cb25f-50d5-4895-9bd2-9326ef951a25{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}2 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{2Citationpaper:272cb25f-50d5-4895-9bd2-9326ef951a25{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}3 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{2Citationpaper:272cb25f-50d5-4895-9bd2-9326ef951a25{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}4 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{2Citationpaper:272cb25f-50d5-4895-9bd2-9326ef951a25{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}5 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{2Citationpaper:272cb25f-50d5-4895-9bd2-9326ef951a25{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}6 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{2Citationpaper:272cb25f-50d5-4895-9bd2-9326ef951a25{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}7 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{2Citationpaper:272cb25f-50d5-4895-9bd2-9326ef951a25{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}8 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{2Citationpaper:272cb25f-50d5-4895-9bd2-9326ef951a25{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}9 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{3Citationpaper:paper-b6fa1f4bb5fd{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}0 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{3Citationpaper:paper-b6fa1f4bb5fd{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}1 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{3Citationpaper:paper-b6fa1f4bb5fd{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}2 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{3Citationpaper:paper-b6fa1f4bb5fd{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}3 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{3Citationpaper:paper-b6fa1f4bb5fd{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}4 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{3Citationpaper:paper-b6fa1f4bb5fd{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}5 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{3Citationpaper:paper-b6fa1f4bb5fd{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}6 {ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...
^{3Citationpaper:paper-b6fa1f4bb5fd{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}7 The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously ^{3Citationpaper:paper-b6fa1f4bb5fd{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}8; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...
^{3Citationpaper:paper-b6fa1f4bb5fd{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}9 The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously ^{4Citationpaper:paper-4d148ae6ffa9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}0; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...
^{4Citationpaper:paper-4d148ae6ffa9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}1 The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously ^{4Citationpaper:paper-4d148ae6ffa9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}2; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...
^{4Citationpaper:paper-4d148ae6ffa9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}3 The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously ^{4Citationpaper:paper-4d148ae6ffa9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}4; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...
^{4Citationpaper:paper-4d148ae6ffa9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}5 The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously ^{4Citationpaper:paper-4d148ae6ffa9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}6; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...
^{4Citationpaper:paper-4d148ae6ffa9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}7 The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously ^{4Citationpaper:paper-4d148ae6ffa9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}8; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...
^{4Citationpaper:paper-4d148ae6ffa9{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}9 The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously ^{5Citationpaper:577e8d9c-6914-4e20-884c-e57013fb6564{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}0; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...
^{5Citationpaper:577e8d9c-6914-4e20-884c-e57013fb6564{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}1 The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously ^{5Citationpaper:577e8d9c-6914-4e20-884c-e57013fb6564{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}2; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...
^{5Citationpaper:577e8d9c-6914-4e20-884c-e57013fb6564{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}3 The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously ^{5Citationpaper:577e8d9c-6914-4e20-884c-e57013fb6564{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}4; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...
^{5Citationpaper:577e8d9c-6914-4e20-884c-e57013fb6564{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}5 In-vivo two-photon calcium imaging defines the population-imaging baseline. GCaMP6 reliably detects single action potentials in L2/3 pyramidal somata and orientation-tuned synaptic transients in individual spines of awake mouse V1, with structurally persistent spine tuning over weeks ^{5Citationpaper:577e8d9c-6914-4e20-884c-e57013fb6564{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}6. The jGCaMP7 indicator family supplies variants optimised for single-spike detection, neurite/neuropil imaging, and wide-fi...
^{5Citationpaper:577e8d9c-6914-4e20-884c-e57013fb6564{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}7 In-vivo two-photon calcium imaging defines the population-imaging baseline. GCaMP6 reliably detects single action potentials in L2/3 pyramidal somata and orientation-tuned synaptic transients in individual spines of awake mouse V1, with structurally persistent spine tuning over weeks ^{5Citationpaper:577e8d9c-6914-4e20-884c-e57013fb6564{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}8. The jGCaMP7 indicator family supplies variants optimised for single-spike detection, neurite/neuropil imaging, and wide-fi...
^{5Citationpaper:577e8d9c-6914-4e20-884c-e57013fb6564{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}9 In-vivo two-photon calcium imaging defines the population-imaging baseline. GCaMP6 reliably detects single action potentials in L2/3 pyramidal somata and orientation-tuned synaptic transients in individual spines of awake mouse V1, with structurally persistent spine tuning over weeks ^{6Citationpaper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}0. The jGCaMP7 indicator family supplies variants optimised for single-spike detection, neurite/neuropil imaging, and wide-fi...
^{6Citationpaper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}1 In-vivo two-photon calcium imaging defines the population-imaging baseline. GCaMP6 reliably detects single action potentials in L2/3 pyramidal somata and orientation-tuned synaptic transients in individual spines of awake mouse V1, with structurally persistent spine tuning over weeks ^{6Citationpaper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}2. The jGCaMP7 indicator family supplies variants optimised for single-spike detection, neurite/neuropil imaging, and wide-fi...
^{6Citationpaper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}3 In-vivo two-photon calcium imaging defines the population-imaging baseline. GCaMP6 reliably detects single action potentials in L2/3 pyramidal somata and orientation-tuned synaptic transients in individual spines of awake mouse V1, with structurally persistent spine tuning over weeks ^{6Citationpaper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}4. The jGCaMP7 indicator family supplies variants optimised for single-spike detection, neurite/neuropil imaging, and wide-fi...
^{6Citationpaper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}5 In-vivo two-photon calcium imaging defines the population-imaging baseline. GCaMP6 reliably detects single action potentials in L2/3 pyramidal somata and orientation-tuned synaptic transients in individual spines of awake mouse V1, with structurally persistent spine tuning over weeks ^{6Citationpaper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}6. The jGCaMP7 indicator family supplies variants optimised for single-spike detection, neurite/neuropil imaging, and wide-fi...
^{6Citationpaper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}7 In-vivo two-photon calcium imaging defines the population-imaging baseline. GCaMP6 reliably detects single action potentials in L2/3 pyramidal somata and orientation-tuned synaptic transients in individual spines of awake mouse V1, with structurally persistent spine tuning over weeks ^{6Citationpaper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}8. The jGCaMP7 indicator family supplies variants optimised for single-spike detection, neurite/neuropil imaging, and wide-fi...
^{6Citationpaper:f9da5cad-8241-41b3-8528-a8e55cc5f0e1{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}9 Voltage imaging is the tool meant to break the spike-timing and subthreshold ceilings, and its present envelope is tighter than calcium imaging by every relevant axis (Figure {ref}fig-sec15-voltage-imaging-limits). JEDI-2P, engineered specifically for two-photon excitation, sustains voltage recording from individual cortical neurons for more than 30 minutes and detects spikes beyond 400 µm using ULoVE random-acces...
^{7Citationpaper:paper-89a449ba5293{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}0 Voltage imaging is the tool meant to break the spike-timing and subthreshold ceilings, and its present envelope is tighter than calcium imaging by every relevant axis (Figure {ref}fig-sec15-voltage-imaging-limits). JEDI-2P, engineered specifically for two-photon excitation, sustains voltage recording from individual cortical neurons for more than 30 minutes and detects spikes beyond 400 µm using ULoVE random-acces...
^{7Citationpaper:paper-89a449ba5293{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}1 Voltage imaging is the tool meant to break the spike-timing and subthreshold ceilings, and its present envelope is tighter than calcium imaging by every relevant axis (Figure {ref}fig-sec15-voltage-imaging-limits). JEDI-2P, engineered specifically for two-photon excitation, sustains voltage recording from individual cortical neurons for more than 30 minutes and detects spikes beyond 400 µm using ULoVE random-acces...
^{7Citationpaper:paper-89a449ba5293{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}2 Voltage imaging is the tool meant to break the spike-timing and subthreshold ceilings, and its present envelope is tighter than calcium imaging by every relevant axis (Figure {ref}fig-sec15-voltage-imaging-limits). JEDI-2P, engineered specifically for two-photon excitation, sustains voltage recording from individual cortical neurons for more than 30 minutes and detects spikes beyond 400 µm using ULoVE random-acces...
^{7Citationpaper:paper-89a449ba5293{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}3 Voltage imaging is the tool meant to break the spike-timing and subthreshold ceilings, and its present envelope is tighter than calcium imaging by every relevant axis (Figure {ref}fig-sec15-voltage-imaging-limits). JEDI-2P, engineered specifically for two-photon excitation, sustains voltage recording from individual cortical neurons for more than 30 minutes and detects spikes beyond 400 µm using ULoVE random-acces...
^{7Citationpaper:paper-89a449ba5293{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}4 Voltage imaging is the tool meant to break the spike-timing and subthreshold ceilings, and its present envelope is tighter than calcium imaging by every relevant axis (Figure {ref}fig-sec15-voltage-imaging-limits). JEDI-2P, engineered specifically for two-photon excitation, sustains voltage recording from individual cortical neurons for more than 30 minutes and detects spikes beyond 400 µm using ULoVE random-acces...
^{7Citationpaper:paper-89a449ba5293{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}5 A biophysical model concludes that with JEDI-2P in mouse cortex at SNR 10 (spike-to-shot-noise), 1-kHz bandwidth and an 80-MHz source, no more than ≈12 neurons can be recorded simultaneously beyond 300 µm ^{7Citationpaper:paper-89a449ba5293{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}6. The empirical JEDI-2P paper detects spikes beyond 400 µm with ULoVE random-access scanning and reports voltage correlations in cell pairs ^{7Citationpaper:paper-89a449ba5293{ref}sec-predictive-coding closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...content/15_methods_limits.md:line 5Open reference}7. The conflict resolves into different operating...
... 85 additional anchors in refs_json

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[Sorensen2023] paper:paper-pm-38168270 “{ref}`sec-predictive-coding` closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...”
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[Tasic2016] paper:paper-ed2a7f08ef35 “{ref}`sec-predictive-coding` closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...”
[Yao2023b] paper:1f98e15e-de06-42f7-9da8-1faa69bba835 “{ref}`sec-predictive-coding` closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...”
[Zhang2023b] paper:paper-748279add05a “{ref}`sec-predictive-coding` closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...”
[Saunders2018] paper:paper-a5fcb640f059 “{ref}`sec-predictive-coding` closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...”
[Susaki2014] paper:paper-622bfe2cb817 “{ref}`sec-predictive-coding` closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...”
[Renier2014] paper:paper-697b07e8c7cc “{ref}`sec-predictive-coding` closed the theoretical assessments of predictive coding and dynamical-systems accounts of mouse cortex; those assessments rest on what the present toolkit can measure. This section names three measurement ceilings that bound the mouse-cortex E→E literature: no tool images subthreshold network activity at scale, fast in-vivo plasticity at identified pyramidal–pyramidal synapses is not rou...”
[Windolf2025] paper:paper-793e4c49a0ab “The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously [Jun2017]; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...”
[InternationalBrainLaboratory2025a] paper:paper-2b761af080cf “The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously [Jun2017]; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...”
[Lakunina2025] paper:paper-8e8580930f6f “The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously [Jun2017]; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...”
[Sibille2024] paper:paper-a68257c65174 “The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously [Jun2017]; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...”
[Jain2025] paper:paper-4f71f7f4e5d3 “The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously [Jun2017]; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...”
[Meszena2026] paper:paper-00c3f5834d31 “The current Neuropixels baseline is the operating point against which every ceiling is read. The original probe integrates 384 simultaneously recorded channels on a single 10-mm shank, and two probes recorded over 700 well-isolated single neurons across five awake-mouse structures simultaneously [Jun2017]; Neuropixels 2.0 then added chronic stability — same-neuron recording across more than two months from greater t...”
[Matveev2024] paper:paper-20368a7b716c “In-vivo two-photon calcium imaging defines the population-imaging baseline. GCaMP6 reliably detects single action potentials in L2/3 pyramidal somata and orientation-tuned synaptic transients in individual spines of awake mouse V1, with structurally persistent spine tuning over weeks [Chen2013]. The jGCaMP7 indicator family supplies variants optimised for single-spike detection, neurite/neuropil imaging, and wide-fi...”
[Lin2016] paper:paper-1c782ef3dca9 “In-vivo two-photon calcium imaging defines the population-imaging baseline. GCaMP6 reliably detects single action potentials in L2/3 pyramidal somata and orientation-tuned synaptic transients in individual spines of awake mouse V1, with structurally persistent spine tuning over weeks [Chen2013]. The jGCaMP7 indicator family supplies variants optimised for single-spike detection, neurite/neuropil imaging, and wide-fi...”
[Grimm2026] paper:paper-45a8cfabfd65 “Voltage imaging is the tool meant to break the spike-timing and subthreshold ceilings, and its present envelope is tighter than calcium imaging by every relevant axis (Figure {ref}`fig-sec15-voltage-imaging-limits`). JEDI-2P, engineered specifically for two-photon excitation, sustains voltage recording from individual cortical neurons for more than 30 minutes and detects spikes beyond 400 µm using ULoVE random-acces...”
[Xiao2024b] paper:paper-735d6ec54860 “Voltage imaging is the tool meant to break the spike-timing and subthreshold ceilings, and its present envelope is tighter than calcium imaging by every relevant axis (Figure {ref}`fig-sec15-voltage-imaging-limits`). JEDI-2P, engineered specifically for two-photon excitation, sustains voltage recording from individual cortical neurons for more than 30 minutes and detects spikes beyond 400 µm using ULoVE random-acces...”
[PhilBrooks2024] paper:paper-ed927db80f97 “A biophysical model concludes that with JEDI-2P in mouse cortex at SNR 10 (spike-to-shot-noise), 1-kHz bandwidth and an 80-MHz source, no more than ≈12 neurons can be recorded simultaneously beyond 300 µm [PhilBrooks2024]. The empirical JEDI-2P paper detects spikes beyond 400 µm with ULoVE random-access scanning and reports voltage correlations in cell pairs [Liu2022a]. The conflict resolves into different operating...”

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