- raw_fields
{
"n": 549,
"doi": "10.1007/s00702-019-02080-2",
"claim": "PV interneurons are reduced in density in the frontal cortex of schizophrenia patients, with a small but significant effect size, while PV mRNA reductions are non-significant.",
"evidence": "PV interneurons are reduced in density in the frontal cortex of schizophrenia patients, with a small but significant effect size, while PV mRNA reductions are non-significant.",
"effect_size": "Hedges' g = -0.27 (p=0.03) for cell density; g = -0.44 (p=0.12) for mRNA",
"text_access": "fulltext",
"study_system": "Human postmortem brain tissue, schizophrenia patients vs controls",
"replication_status": "independently_replicated",
"claim_source_sentence": "The results suggest that parvalbumin interneurons are reduced in density in the frontal cortex of patients with schizophrenia (Hedges' g = - 0.27; p = 0.03) and there is a non-significant reduction in parvalbumin mRNA levels (g = - 0.44; p = 0.12).",
"replication_evidence_dois": [
"10.1093/schbul/sbad123",
"10.3389/fphar.2021.689473"
],
"effect_size_source_sentence": "The results suggest that parvalbumin interneurons are reduced in density in the frontal cortex of patients with schizophrenia (Hedges' g = - 0.27; p = 0.03) and there is a non-significant reduction in parvalbumin mRNA levels (g = - 0.44; p = 0.12)."
}- source_refs
[
"paper:paper-8a23937e9dab"
]
- source_span
The results suggest that parvalbumin interneurons are reduced in density in the frontal cortex of patients with schizophrenia (Hedges' g = - 0.27; p = 0.03) and there is a non-significant reduction in parvalbumin mRNA levels (g = - 0.44; p = 0.12).
- evidence_refs
[
{
"ref": "paper:paper-8a23937e9dab"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}