Details

scope
Mouse astroglia-to-neuron reprogramming
claim_text
Astroglia can be reprogrammed into neurons with hallmarks of fast-spiking PV interneurons, demonstrating that the fast-spiking phenotype can emerge from non-neuronal precursors under appropriate transcriptional programs.
section_id
section_13_evidence_package
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json
review_repo
ComputationalReviewPV
section_ref
wiki_page:computationalreviewpv-13
source_kind
review_finding
source_path
evidence/section_13_evidence_package.json
source_span
Reprogramming astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons.
study_system
Mouse astroglia-to-neuron reprogramming
section_title
Cross-Cluster Synthesis: What Replicates, What Is Contested, What Is Untested
evidence_summary
Astroglia can be reprogrammed into neurons with hallmarks of fast-spiking PV interneurons, demonstrating that the fast-spiking phenotype can emerge from non-neuronal precursors under appropriate transcriptional programs.
review_bundle_ref
analysis_bundle:ab-e6261c8263e7
replication_status
replication_unknown
review_package_ref
analysis_bundle:ab-e6261c8263e7
source_artifact_ref
wiki_page:computationalreviewpv-13
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json
commit_sha
df9fc7e8d455b084152c9d713558dae0013cef21
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
raw_fields
{
  "n": 0,
  "doi": "10.1126/sciadv.adl5935",
  "claim": "Astroglia can be reprogrammed into neurons with hallmarks of fast-spiking PV interneurons, demonstrating that the fast-spiking phenotype can emerge from non-neuronal precursors under appropriate transcriptional programs.",
  "evidence": "Astroglia can be reprogrammed into neurons with hallmarks of fast-spiking PV interneurons, demonstrating that the fast-spiking phenotype can emerge from non-neuronal precursors under appropriate transcriptional programs.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "Mouse astroglia-to-neuron reprogramming",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Reprogramming astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-31bfed21e7b5"
]
evidence_refs
[
  {
    "ref": "paper:paper-31bfed21e7b5"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

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