Details

scope
Human postmortem brain tissue, schizophrenia subjects
claim_text
PNN density was consistently reduced in schizophrenia across different brain regions (6 of 7 studies), but tissue processing methodologies were heterogeneous and the evidence base remains small.
section_id
section_13_evidence_package
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json
effect_size
6/7 studies showed significant PNN reductions
review_repo
ComputationalReviewPV
section_ref
wiki_page:computationalreviewpv-13
source_kind
review_finding
source_path
evidence/section_13_evidence_package.json
study_system
Human postmortem brain tissue, schizophrenia subjects
section_title
Cross-Cluster Synthesis: What Replicates, What Is Contested, What Is Untested
evidence_summary
PNN density was consistently reduced in schizophrenia across different brain regions (6 of 7 studies), but tissue processing methodologies were heterogeneous and the evidence base remains small.
review_bundle_ref
analysis_bundle:ab-e6261c8263e7
replication_status
independently_replicated
review_package_ref
analysis_bundle:ab-e6261c8263e7
source_artifact_ref
wiki_page:computationalreviewpv-13
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_13_evidence_package.json
commit_sha
df9fc7e8d455b084152c9d713558dae0013cef21
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (5)
raw_fields
{
  "n": 7,
  "doi": "10.1016/j.schres.2024.07.023",
  "claim": "PNN density was consistently reduced in schizophrenia across different brain regions (6 of 7 studies), but tissue processing methodologies were heterogeneous and the evidence base remains small.",
  "evidence": "PNN density was consistently reduced in schizophrenia across different brain regions (6 of 7 studies), but tissue processing methodologies were heterogeneous and the evidence base remains small.",
  "effect_size": "6/7 studies showed significant PNN reductions",
  "text_access": "fulltext",
  "study_system": "Human postmortem brain tissue, schizophrenia subjects",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Results consisted of 7 studies that were included in the final analysis. Findings were mostly positive for reduced PNN density in SCZ, with 6 of the 7 studies reporting significant reductions and one reporting a tendency towards reduced PNN density.",
  "replication_evidence_dois": [
    "10.1007/s00702-019-02080-2"
  ],
  "effect_size_source_sentence": "Findings were mostly positive for reduced PNN density in SCZ, with 6 of the 7 studies reporting significant reductions and one reporting a tendency towards reduced PNN density."
}
source_refs
[
  "paper:paper-ae472e8a4809"
]
source_span
Results consisted of 7 studies that were included in the final analysis. Findings were mostly positive for reduced PNN density in SCZ, with 6 of the 7 studies reporting significant reductions and one reporting a tendency towards reduced PNN density.
evidence_refs
[
  {
    "ref": "paper:paper-ae472e8a4809"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

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