In mouse somatosensory cortex, PV-, SST-, and 5-HT3aR-expressing neurons togeth…

In mouse somatosensory cortex, PV-, SST-, and 5-HT3aR-expressing neurons together account for nearly 100% of GABAergic interneurons; ~40% of VIP cells co-express calretinin and all VIP neurons express 5-HT3aR; VIP cells have among the highest input resistance and are dendrite-targeting, with rare basket-type morphologies.

{
  "n": null,
  "doi": "10.1002/dneu.20853",
  "claim": "In mouse somatosensory cortex, PV-, SST-, and 5-HT3aR-expressing neurons together account for nearly 100% of GABAergic interneurons; ~40% of VIP cells co-express calretinin and all VIP neurons express 5-HT3aR; VIP cells have among the highest input resistance and are dendrite-targeting, with rare basket-type morphologies.",
  "title": null,
  "cite_key": "Rudy2011",
  "evidence": "Cumulative review of immunohistochemistry, transgenic and electrophysiological studies in mouse cortex.",
  "effect_size": "Three groups account for ~100%; ~40% of VIP cells express CR; VIP cells have highest input resistance.",
  "text_access": "fulltext",
  "study_system": "mouse cortex (review/synthesis)",
  "_source_cluster": "cluster_05_synaptic_connectivity",
  "replication_status": "replicated",
  "_source_cluster_index": 20,
  "claim_source_sentence": "The conclusion that PV-, SST-, and 5HT3aR-expressing neurons account for nearly if not all GABAergic interneurons in mouse somatosensory cortex implies that other interneuron markers such as the neuropeptides VIP, NPY, and cholecystokinin (CCK) and the Ca 2+ -binding proteins cal",
  "replication_evidence_dois": [
    "10.1002/cne.21948"
  ],
  "effect_size_source_sentence": "A significant fraction of VIP neurons (40%) express CR, which, as described earlier, is also expressed in a fraction of SST neurons, as well as in interneurons that do not express VIP or SST"
}

[
  "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9"
]

The conclusion that PV-, SST-, and 5HT3aR-expressing neurons account for nearly if not all GABAergic interneurons in mouse somatosensory cortex implies that other interneuron markers such as the neuropeptides VIP, NPY, and cholecystokinin (CCK) and the Ca 2+ -binding proteins cal

[
  {
    "ref": "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}