- claim_text
PV-, SST- and 5HT3aR-expressing cortical interneurons together account for nearly 100% of GABAergic neurons in mouse somatosensory cortex, with the 5HT3aR group (which contains all VIP+ cells plus VIP-negative L1/Lamp5 cells) forming the third major group whose intrinsic electrophysiology is the most heterogeneous.
- raw_fields
{
"n": null,
"doi": "10.1002/dneu.20853",
"claim": "PV-, SST- and 5HT3aR-expressing cortical interneurons together account for nearly 100% of GABAergic neurons in mouse somatosensory cortex, with the 5HT3aR group (which contains all VIP+ cells plus VIP-negative L1/Lamp5 cells) forming the third major group whose intrinsic electrophysiology is the most heterogeneous.",
"title": null,
"cite_key": "Rudy2011",
"evidence": "review compiling 5HT3aR-BAC EGFP genetic targeting + scRT-PCR/IHC overlap data in mouse S1",
"effect_size": "PV + SST + 5HT3aR ≈ 100% of cortical GABAergic INs (S1)",
"text_access": "fulltext",
"study_system": "review of mouse cortical interneuron taxonomy",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replicated",
"_source_cluster_index": 45,
"claim_source_sentence": "This analysis has provided strong evidence that three major groups of neurons, those expressing the Ca 2+ -binding protein parvalbumin (PV), those expressing the neuropeptide somatostatin (SST), and those expressing 5HT3aRs account for nearly 100% of GABAergic neurons in somatose...",
"replication_evidence_dois": [
"10.1523/jneurosci.1869-10.2010"
],
"effect_size_source_sentence": "three major groups of neurons, those expressing the Ca 2+ -binding protein parvalbumin (PV), those expressing the neuropeptide somatostatin (SST), and those expressing 5HT3aRs account for nearly 100% of GABAergic neurons in somatosensory cortex."
}- source_refs
[
"paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9"
]
- source_span
This analysis has provided strong evidence that three major groups of neurons, those expressing the Ca 2+ -binding protein parvalbumin (PV), those expressing the neuropeptide somatostatin (SST), and those expressing 5HT3aRs account for nearly 100% of GABAergic neurons in somatose...
- evidence_refs
[
{
"ref": "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}