All neocortical VIP-expressing GABAergic interneurons fall within the 5HT3aR-ex…

All neocortical VIP-expressing GABAergic interneurons fall within the 5HT3aR-expressing group; a roughly equally numerous 5HT3aR-positive but VIP-negative subgroup that includes neurogliaform cells (reelin-positive) accounts for the rest of the 5HT3aR class, which itself constitutes ~30% of cortical interneurons.

{
  "n": null,
  "doi": "10.1002/dneu.20853",
  "claim": "All neocortical VIP-expressing GABAergic interneurons fall within the 5HT3aR-expressing group; a roughly equally numerous 5HT3aR-positive but VIP-negative subgroup that includes neurogliaform cells (reelin-positive) accounts for the rest of the 5HT3aR class, which itself constitutes ~30% of cortical interneurons.",
  "title": null,
  "cite_key": "Rudy2011",
  "evidence": "Review of multiple molecular profiling and 5HT3a-Cre fate-mapping studies; PV (~40%), SST (~30%), 5HT3aR (~30%) collectively account for nearly 100% of neocortical interneurons in mouse somatosensory cortex.",
  "effect_size": "5HT3aR group ≈ 30% of cortical interneurons; ~50% of these are VIP+ and ~50% VIP-/reelin+/neurogliaform-type",
  "figure_data": [
    {
      "type": "population_fraction",
      "unit": "percent",
      "value": 40,
      "metric": "% cortical interneurons in PV group",
      "source": "Lee/Rudy 2011 review",
      "context": "remaining ~30% SST + ~30% 5HT3aR (all VIP+)"
    },
    {
      "type": "population_fraction",
      "unit": "percent",
      "value": 30,
      "metric": "% cortical interneurons in 5HT3aR group",
      "source": "Lee/Rudy 2011 review",
      "context": "encompasses all VIP+ plus ~equal VIP-/reelin+ neurogliaform cells"
    }
  ],
  "text_access": "fulltext",
  "study_system": "mouse, somatosensory cortex (review/meta)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "review",
  "_source_cluster_index": 83,
  "claim_source_sentence": "The 5HT3aR group, which also accounts for ~30% of the total interneuronal population, is heterogeneous and includes all of the neurons that express the neuropeptide VIP, as well as an equally numerous subgroup of neurons that do not express VIP and includes neurogliaform cells.",
  "replication_evidence_dois": [
    "10.1523/jneurosci.1869-10.2010",
    "10.1038/nrn3444"
  ],
  "effect_size_source_sentence": "The PV group accounts for ~40% of GABAergic neurons and includes fast spiking basket cells and chandelier cells. The SST group, which represents ~30% of GABAergic neurons, includes the Martinotti cells and a set of neurons that specifically target layer IV. The 5HT3aR group, which also accounts for ~30% of the total interneuronal population, is heterogeneous and includes all of the neurons that express the neuropeptide VIP, as well as an equally numerous subgroup of neurons that do not express VIP and includes neurogliaform cells."
}

[
  "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9"
]

The 5HT3aR group, which also accounts for ~30% of the total interneuronal population, is heterogeneous and includes all of the neurons that express the neuropeptide VIP, as well as an equally numerous subgroup of neurons that do not express VIP and includes neurogliaform cells.

[
  {
    "ref": "paper:34a07597-2d6f-4552-b9cf-d2d11817f9f9"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}