Details

scope
Q4_alzheimer
claim_text
The interneuron energy hypothesis: Implications for brain disease
section_id
section_11_evidence_package
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
review_repo
ComputationalReviewPV
section_ref
wiki_page:computationalreviewpv-11
source_kind
review_finding
source_path
evidence/section_11_evidence_package.json
study_system
Q4_alzheimer
section_title
Species Translation, Human Data, and Disease Models
evidence_summary
Study on PV interneuron alterations in schizophrenia
review_bundle_ref
analysis_bundle:ab-e6261c8263e7
replication_status
independently_replicated
review_package_ref
analysis_bundle:ab-e6261c8263e7
source_artifact_ref
wiki_page:computationalreviewpv-11
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_11_evidence_package.json
commit_sha
df9fc7e8d455b084152c9d713558dae0013cef21
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (5)
raw_fields
{
  "n": 0,
  "doi": "10.1016/j.nbd.2015.08.005",
  "claim": "The interneuron energy hypothesis: Implications for brain disease",
  "evidence": "Study on PV interneuron alterations in schizophrenia",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "Q4_alzheimer",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Fast-spiking, inhibitory interneurons - prototype is the parvalbumin-positive (PV+) basket cell - generate action potentials at high frequency and synchronize the activity of numerous excitatory principal neurons, such as pyramidal cells, during fast network oscillations by rhythmic inhibition.",
  "replication_evidence_dois": [
    "10.1038/jcbfm.2014.104",
    "10.1073/pnas.1300454110"
  ],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-d06cb01881bd"
]
source_span
Fast-spiking, inhibitory interneurons - prototype is the parvalbumin-positive (PV+) basket cell - generate action potentials at high frequency and synchronize the activity of numerous excitatory principal neurons, such as pyramidal cells, during fast network oscillations by rhythmic inhibition.
evidence_refs
[
  {
    "ref": "paper:paper-d06cb01881bd"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

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