Early theoretical analysis of cortical inhibitory subtype division-of-labor (PV…

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  "doi": "10.1073/pnas.0305337101",
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  "claim": "Early theoretical analysis of cortical inhibitory subtype division-of-labor (PV vs SST vs VIP) establishes that compartment-specific inhibition supports differential gain control on dendrites vs soma.",
  "pmcid": "PMC337059",
  "title": "Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory.",
  "authors": "Wang XJ, Tegnér J, Constantinidis C, Goldman-Rakic PS.",
  "journal": "Proceedings of the National Academy of Sciences of the United States of America",
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In a model designed for spatial working memory, stimulus tuning of persistent activity arises from the concerted action of widespread inhibition mediated by perisoma-targeting (parvalbumin-containing) interneurons and localized disinhibition of pyramidal cells via interneuron-targeting (calretinin-containing) interneurons.

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