Details
- scope
- rat hippocampus
- claim_text
- We found that inhibitory inputs from somatostatin (SST) and parvalbumin (PV)-positive interneurons onto CA1 PCs display input-specific long-term plastic changes following transient NMDA receptor activation.
- section_id
- section_06_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json
- effect_size
- Interestingly, 30 min after NMDA administration for 2′30′′ excitatory CA3 → CA1 synapses expressed excitatory long-term depression (eLTD) (average EPSC before: 141.6 ± 19.6 pA, after: 109.0 ± 20.8 pA, n = 25, p = 0.002, paired t-test ).
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-06
- source_kind
- review_finding
- source_path
- evidence/section_06_evidence_package.json
- source_span
- We found that inhibitory inputs from somatostatin (SST) and parvalbumin (PV)-positive interneurons onto CA1 PCs display input-specific long-term plastic changes following transient NMDA receptor activation.
- study_system
- rat hippocampus
- section_title
- Synaptic Physiology: Input Specificity, Output Targeting, and Short-Term Dynamics
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- within_lab_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-06
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_06_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (5)
- raw_fields
{ "n": 92, "doi": "10.1038/s41598-024-70278-w", "claim": "We found that inhibitory inputs from somatostatin (SST) and parvalbumin (PV)-positive interneurons onto CA1 PCs display input-specific long-term plastic changes following transient NMDA receptor activation.", "evidence": "Sensory experiences and learning induce long-lasting changes in both excitatory and inhibitory synapses, thereby providing a crucial substrate for memory. However, the co-tuning of excitatory long-term potentiation (eLTP) or depression (eLTD) with the simultaneous changes at inhibitory synapses (iLT", "effect_size": "Interestingly, 30 min after NMDA administration for 2′30′′ excitatory CA3 → CA1 synapses expressed excitatory long-term depression (eLTD) (average EPSC before: 141.6 ± 19.6 pA, after: 109.0 ± 20.8 pA, n = 25, p = 0.002, paired t-test ).", "text_access": "fulltext", "study_system": "rat hippocampus", "replication_status": "within_lab_replicated", "claim_source_sentence": "We found that inhibitory inputs from somatostatin (SST) and parvalbumin (PV)-positive interneurons onto CA1 PCs display input-specific long-term plastic changes following transient NMDA receptor activation.", "replication_evidence_dois": [], "effect_size_source_sentence": "Interestingly, 30 min after NMDA administration for 2′30′′ excitatory CA3 → CA1 synapses expressed excitatory long-term depression (eLTD) (average EPSC before: 141.6 ± 19.6 pA, after: 109.0 ± 20.8 pA, n = 25, p = 0.002, paired t-test )." }- source_refs
[ "paper:paper-6634769ed2ab" ]
- evidence_refs
[ { "ref": "paper:paper-6634769ed2ab" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }- evidence_summary
Sensory experiences and learning induce long-lasting changes in both excitatory and inhibitory synapses, thereby providing a crucial substrate for memory. However, the co-tuning of excitatory long-term potentiation (eLTP) or depression (eLTD) with the simultaneous changes at inhibitory synapses (iLT