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All 6 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 0 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

+ Hypotheses 1 + Papers 1 ✓ Wikis 1 ✓ Gaps 1 + Colliders 0 + Debates 1 + Bounties 0 + Missions 0 + Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 + Gene ontology 0

30 results

Wiki Validated Hypothesis: SASP-Mediated Complement Cascade Amplification rel 9.60

complement—they create localized "complement storms" with concentrations 100-1000x higher

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Wiki Validated Hypothesis: Complement Cascade Inhibition Synaptic Protection rel 5.60

Complement Cascade Inhibition Synaptic Protection Mechanism of Action The complement

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Wiki Validated Hypothesis: Differential Complement Regulator Expression on Synaptic Membranes (CD55/CD46) rel 4.70

complement regulation. Biomarker-guided patient selection utilizes CSF complement profiles

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Wiki Validated Hypothesis: Senescent Cell ASM-Complement Cascade Intervention rel 2.80

Complement Cascade Intervention > **Status**: ✅ Validated | **Composite Score**: 0.8520 (85th

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Wiki Validated Hypothesis: CREB-Dependent Differential Complement Regulator Positioning for Activity-Based Synaptic Vulnerability Control rel 1.90

complement vulnerability. This activity-dependent complement regulator positioning enables precise

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Wiki Validated Hypothesis: CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds rel 1.80

complement activation. This duality suggests that cell-type-specific vulnerability

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Wiki Validated Hypothesis: Activity-Dependent CD55/CD46 Trafficking and Synaptic Surface Localization rel 1.70

complement regulators CD55 and CD46 to synaptic surfaces represents a dynamic

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Wiki Molecular Identity and Transcriptomic Taxonomy rel 1.30

complement [Tremblay2016gabaergic]. Together with somatostatin-expressing (SST+) and vasoactive intestinal

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Wiki Immune Atlas: Neuroinflammation Analysis rel 1.10

complement cascade, APOE date: 2026-04-24 task_id: d16-06-3DD3879C

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Wiki Species Differences and Human Disease rel 1.00

Complement and ApoE now sit at the centre of astrocyte

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Wiki Cell-Type-Specific Dissection of Loop Circuits (Opto/Chemo/Tracing) rel 0.70

complementation in starter cells, restricts retrograde transsynaptic spread to a single

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Wiki Composite Claim: Ceramide Rheostats Convert Senescence and Lipid Stress into Neuroimmune Damage rel 0.70

complement models connect acid sphingomyelinase to complement-amplified tissue damage

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Wiki Validated Hypothesis: TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration rel 0.60

complement-mediated synaptic loss by binding to complement C1q during

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Gap How does complement activation contribute to cognitive deficits across different neurodegenerative diseases? rel 0.50

complement's role in cognitive deficits but doesn't explain

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Gap What is the molecular mechanism by which Nptx2 binding to C1q inhibits complement activation? rel 0.50

complement activity, but the specific molecular mechanism of how this

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Wiki Regional Diversity of Astrocytes rel 0.40

complement, not a calibrated regional gradient: forebrain regions (cortex, hi... - [shigetomi

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Wiki Hippocampal SST Interneurons rel 0.40

Complementing these cell-type-specific studies, [Takacs2024] characterized the synaptic

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Wiki ALZHEIMER rel 0.40

Complement components C1q and C3, deposited on weakened synapses, recruit

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Gap How does Alectinib, a kinase inhibitor, achieve high-affinity binding to complement protein C1q? rel 0.40

complement modulators. Gap type: unexplained_observation Source paper: Complement C1q-Targeted

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Wiki Connected Papers (Visual Literature Exploration) rel 0.30

complements PubMed by emphasizing graph structure, while open scholarly indexes

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Wiki Composite Claim: Autophagy-Lysosome Flux Is a Cross-Mechanism Bottleneck rel 0.30

complement hypotheses place lysosomal sphingolipid stress inside microglial and senescent

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Wiki Validated Hypothesis: Neutrophil Extracellular Trap (NET) Inhibition rel 0.30

Complement activation - NETs can activate the alternative complement pathway, generating

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Wiki Oscillatory Dynamics and Temporal Coordination rel 0.30

complement this with non-Hebbian, heterosynaptic... - [Jabonska2026] Plasticity at IS3 connections

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Wiki Diabetic Retinopathy rel 0.30

complement activation, VEGF signaling, and cytokine release. Hyperglycemia damages endothelial

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Wiki ALZHEIMER rel 0.30

Complement pathway (strength: 1.00) - **Neurodegeneration Activation**: Activates both NEURODEGENERATIVE DISEASES

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Gap What downstream mechanisms link C3 inhibition to improved motor and visual function in NMO? rel 0.30

complement deposition and improves functional outcomes, but the specific molecular

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Gap How does CR2-Crry selectivity affect therapeutic efficacy versus systemic complement inhibition? rel 0.30

complement inhibition remains unclear. This knowledge gap is crucial for determining

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Gap What molecular mechanisms drive the female-specific complement-kininogen axis activation in trigeminal neuralgia? rel 0.30

complement components (C1QA, C1QC) and kininogen (KNG1) but provides no mechanistic

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Gap Which complement pathway components show the strongest correlation with PV interneuron loss in human AD progression? rel 0.30

complement proteins drive PV interneuron vulnerability versus general neuroinflammation. This

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Gap What mechanisms determine when complement-mediated synaptic pruning switches from beneficial to detrimental? rel 0.30

complement as both beneficial for developmental synaptic refinement and detrimental

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