Details
- scope
- mouse, mPFC, maternal immune activation model + optogenetics
- claim_text
- Maternal immune activation causes selective functional deficit in PV interneurons associated with impaired attentional set shifting and increased anxiety
- section_id
- section_08_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- effect_size
- selective decrease in PV release probability; impaired set shifting and increased anxiety
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-08
- source_kind
- review_finding
- source_path
- evidence/section_08_evidence_package.json
- source_span
- decreased transmission was selective for interneurons expressing PV, resulted from a decrease in release probability and was not observed in calretinin-expressing neurons
- study_system
- mouse, mPFC, maternal immune activation model + optogenetics
- section_title
- In Vivo Dynamics and Behavioural Correlates
- evidence_summary
- MIA offspring showed reduced GABA transmission from PV cells, impaired attentional set shifting, increased anxiety; optogenetic PV inhibition sufficient to impair set shifting
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-08
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_08_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/mp.2015.222", "claim": "Maternal immune activation causes selective functional deficit in PV interneurons associated with impaired attentional set shifting and increased anxiety", "evidence": "MIA offspring showed reduced GABA transmission from PV cells, impaired attentional set shifting, increased anxiety; optogenetic PV inhibition sufficient to impair set shifting", "effect_size": "selective decrease in PV release probability; impaired set shifting and increased anxiety", "text_access": "fulltext", "study_system": "mouse, mPFC, maternal immune activation model + optogenetics", "replication_status": "replication_unknown", "claim_source_sentence": "decreased transmission was selective for interneurons expressing PV, resulted from a decrease in release probability and was not observed in calretinin-expressing neurons", "replication_evidence_dois": [], "effect_size_source_sentence": "cell-type specific optogenetic inhibition of mPFC PV interneurons was sufficient to impair attentional set shifting and enhance anxiety levels" }- source_refs
[ "paper:paper-ba2d0da09ee5" ]
- evidence_refs
[ { "ref": "paper:paper-ba2d0da09ee5" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }