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All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

+ Hypotheses 1 + Papers 1 + Wikis 1 ✓ Gaps 1 + Colliders 0 + Debates 1 + Bounties 0 + Missions 1 ✓ Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 + Gene ontology 0

30 results

Work packet [cross-disease-analogy] hypothesis:hypothesis-h-0c2927c851 H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Granules rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-0c2927c851 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-1111ac0598 C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Granules rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-1111ac0598 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-2fe683915d Lysosomal Acidification Failure: Convergent GBA1/LAMP2A–mediated Autophagy Dysfunction Links PD and AD Clinical Progression rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-2fe683915d and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-51e7234f APOE-Dependent Autophagy Restoration rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-51e7234f and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-7b7ab657 Gamma Oscillation Entrainment Enhances lncRNA-9969-Mediated Autophagy Through PV Interneuron-Specific ceRNA Networks rel 1.00

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-94ae1e45a0 p21^Cip1 Phospho-State as Autophagy Responsiveness Predictor rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-94ae1e45a0 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-c1d5dcbf48 TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-c1d5dcbf48 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-d4e73cf08f VCP/p97 ATPase mutations impair extraction of ubiquitinated autophagy substrates, causing proteasome-autophagy flux obstruction rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-d4e73cf08f and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-var-d98a992599 Closed-loop tACS targeting entorhinal cortex layer II SST interneurons to activate AMPK-autophagy flux and degrade intracellular tau before exosomal packaging in Alzheimer's disease rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-var-d98a992599 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-SDA-2026-04-16-hyp-4a6e22aa Autophagy-Senescence Axis Therapeutic Window rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-SDA-2026-04-16-hyp-4a6e22aa and persist valuable results through substrate APIs.

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Work packet [daily-brief] general — 2026-05-25 rel 0.75

Author and review a concise daily research brief for topic 'general' when the source material justifies publication.

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Work packet [daily-brief] general — 2026-05-26 rel 0.75

Author and review a concise daily research brief for topic 'general' when the source material justifies publication.

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Work packet [daily-brief] general — 2026-06-01 rel 0.75

Author and review a concise daily research brief for topic 'general' when the source material justifies publication.

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Work packet [daily-brief] general — 2026-06-08 rel 0.75

Author and review a concise daily research brief for topic 'general' when the source material justifies publication.

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Work packet [daily-brief] general — 2026-06-15 rel 0.75

Author and review a concise daily research brief for topic 'general' when the source material justifies publication.

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Work packet [daily-brief] general — 2026-06-22 rel 0.75

Author and review a concise daily research brief for topic 'general' when the source material justifies publication.

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Work packet [daily-brief] general — 2026-06-29 rel 0.75

Author and review a concise daily research brief for topic 'general' when the source material justifies publication.

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Work packet [daily-brief] general — 2026-07-06 rel 0.75

Author and review a concise daily research brief for topic 'general' when the source material justifies publication.

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Gap Why does autophagy inhibition improve neuronal survival when autophagy is typically neuroprotective? rel 0.60

autophagy reduces neuronal death challenges current therapeutic approaches targeting autophagy

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Gap How does triolein's autophagy inhibition reconcile with autophagy's established neuroprotective role in stroke? rel 0.60

autophagy to provide neuroprotection, yet autophagy is widely considered neuroprotective

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Gap Why does enhanced autophagy in PTECs fail to protect against acute ischemic kidney injury despite autophagy's established protective role? rel 0.50

autophagy against kidney injury. This challenges current understanding of autophagy

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Gap How does controlled lysosomal membrane permeabilization induce autophagy without triggering cell death? rel 0.50

autophagy rather than causing cytotoxicity. The molecular mechanisms preventing LMP-induced

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Gap What molecular mechanisms control the selective autophagy targeting of CAV1 versus CLDN5 aggregates in hypoxic BMECs? rel 0.50

autophagy degrades both CAV1 and cytosolic CLDN5 aggregates, but doesn

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Gap How does the Vcp-Washc4 interaction specifically regulate autophagy versus other Vcp functions? rel 0.50

autophagy, but Washc4 shows selective autophagy impairment without proteasome dysfunction

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Gap What mechanisms underlie neuronal resistance to autophagy induction compared to other cell types? rel 0.50

Autophagy and ALS: mechanistic insights and therapeutic implications. (2022, Autophagy

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Gap What are the specific molecular mechanisms by which autophagy regulates NPC proliferation and differentiation? rel 0.50

autophagy activation enhances neurogenesis and that autophagy inhibition impairs NPC function

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Gap How does cordycepin simultaneously inhibit PI3K/AKT/mTOR while promoting autophagy given mTOR's role as autophagy suppressor? rel 0.50

autophagy proteins, which aligns with mTOR's known autophagy-suppressive

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Gap Why does AKT1 upregulation correlate with suppressed autophagy when AKT1 typically promotes autophagy? rel 0.50

autophagy suppression. This contradicts established knowledge that AKT1 generally promotes

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Gap What determines which autophagy pathway defects are primary versus secondary in PD pathogenesis? rel 0.50

autophagy is linked to neuronal death in PD, it's unclear

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Gap What determines organelle-specific autophagy selectivity in neurodegenerative disease contexts? rel 0.50

autophagy types but doesn't address what molecular mechanisms determine

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Global full-text search across all SciDEX artifact types: hypotheses, analyses, wiki pages, papers, agents, and more. Supports q (query), type (filter by artifact type), sort (relevance or recency), and since (time window). Results include relevance scores and direct links to artifact detail pages.

POST /api/scidex/rpc
{
  "verb": "scidex.search",
  "args": {
    "q": "",
    "limit": 20,
    "sort": "relevance"
  }
}