Group I mGluR activation by DHPG enhanced excitatory synaptic transmission in 5…

Group I mGluR activation by DHPG enhanced excitatory synaptic transmission in 54% of fast-spiking interneurons but only 15% of non-fast-spiking interneurons in human supragranular cortex (paired patch-clamp, neurosurgical slices), with conservation between human and rodent for fast-spiking interneurons but species-specific paired-pulse-ratio differences—direct functional evidence for cell-type-specific group-I mGluR modulation in human cortex.

{
  "n": null,
  "doi": "10.3389/fnsyn.2026.1766413",
  "claim": "Group I mGluR activation by DHPG enhanced excitatory synaptic transmission in 54% of fast-spiking interneurons but only 15% of non-fast-spiking interneurons in human supragranular cortex (paired patch-clamp, neurosurgical slices), with conservation between human and rodent for fast-spiking interneurons but species-specific paired-pulse-ratio differences—direct functional evidence for cell-type-specific group-I mGluR modulation in human cortex.",
  "title": null,
  "cite_key": "Sandle2026",
  "evidence": "Paired whole-cell patch-clamp recordings of synaptically connected pyramidal-to-interneuron pairs in human neocortical slices (neurosurgical specimens); DHPG pharmacology; rat comparison.",
  "effect_size": "54% FS vs 15% nFS interneurons showed EPSC enhancement",
  "text_access": "abstract_only",
  "study_system": "human + rat cortex; paired patch-clamp",
  "target_section": "section_05",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replication_supported",
  "_source_cluster_index": 102,
  "claim_source_sentence": "Specifically, we observed acute enhancement of excitatory postsynaptic current (EPSC) amplitudes in 54% of fast-spiking interneurons and in 15% of non-fast-spiking interneuron types. Applying the same experimental protocol in slices from Wistar rats resulted in a similar increase in synaptic strength in fast-spiking interneurons. However, paired-pulse ratio analysis showed species-dependent differences.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "we observed acute enhancement of excitatory postsynaptic current (EPSC) amplitudes in 54% of fast-spiking interneurons and in 15% of non-fast-spiking interneuron types"
}

[
  "paper:paper-9af6e0492426"
]

Specifically, we observed acute enhancement of excitatory postsynaptic current (EPSC) amplitudes in 54% of fast-spiking interneurons and in 15% of non-fast-spiking interneuron types. Applying the same experimental protocol in slices from Wistar rats resulted in a similar increase in synaptic strength in fast-spiking interneurons. However, paired-pulse ratio analysis showed species-dependent differences.

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