- claim_text
Mi et al. (2018) demonstrated that early postmitotic interneuron precursors from MGE and CGE already exhibit distinct transcriptional signatures that map onto cardinal mature types (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6), with Vip bipolar vs multipolar segregation evident before circuit integration.
- raw_fields
{
"n": null,
"doi": "10.1038/nature25999",
"claim": "Mi et al. (2018) demonstrated that early postmitotic interneuron precursors from MGE and CGE already exhibit distinct transcriptional signatures that map onto cardinal mature types (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6), with Vip bipolar vs multipolar segregation evident before circuit integration.",
"title": null,
"cite_key": "Mayer2018",
"evidence": "Drop-seq scRNA-seq of E13.5 MGE and E14.5 CGE/LGE precursors revealed early diversification into mature interneuron classes; Vip class trajectory bifurcates into bipolar and multipolar transcriptomic signatures before cortical entry.",
"effect_size": null,
"text_access": "fulltext",
"study_system": "embryonic mouse MGE/CGE/LGE; Drop-seq scRNA-seq",
"target_section": "section_02",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replicated",
"_source_cluster_index": 24,
"claim_source_sentence": "These could be allocated into non-overlapping cardinal types of cortical interneurons (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6). [Including] clear segregation between Sst Martinotti versus non-Martinotti, Vip bipolar versus multipolar, and Id2 neurogliaform versus non-neurogliaform interneuron subtypes."
}- source_refs
[
"paper:paper-c3e9fd7af6d3"
]
- source_span
These could be allocated into non-overlapping cardinal types of cortical interneurons (Pvalb, Sst, Vip, Id2, Th, Nos1, Igfbp6). [Including] clear segregation between Sst Martinotti versus non-Martinotti, Vip bipolar versus multipolar, and Id2 neurogliaform versus non-neurogliaform interneuron subtypes.
- evidence_refs
[
{
"ref": "paper:paper-c3e9fd7af6d3"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}