Details

scope
whole adult mouse brain; 10x scRNA-seq + MERFISH
claim_text
Yao et al. (2023) reported a whole-brain cell type atlas of adult mouse organized into 34 classes, 338 subclasses, 1,201 supertypes and 5,322 clusters using ~4 million scRNA-seq cells and ~4.3 million MERFISH cells.
section_id
section_02
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json
review_repo
ComputationalReviewVIP
section_ref
wiki_page:computationalreviewvip-02-classification
source_kind
review_finding
source_path
evidence/section_02_evidence_package.json
source_span
The atlas is hierarchically organized into 4 nested levels of classification: 34 classes, 338 subclasses, 1,201 supertypes and 5,322 clusters.
study_system
whole adult mouse brain; 10x scRNA-seq + MERFISH
section_title
Molecular Identity and Transcriptomic Taxonomy
evidence_summary
Combined scRNA-seq (~4M cells QC) + MERFISH (~4.3M cells) on whole adult mouse brain produced hierarchical taxonomy; Vip GABAergic subclass observed across cortex and other regions, with 5,322 leaf clusters.
review_bundle_ref
analysis_bundle:ab-2ce40c33e827
replication_status
replicated
review_package_ref
analysis_bundle:ab-2ce40c33e827
source_artifact_ref
wiki_page:computationalreviewvip-02-classification
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json
commit_sha
95e761177f7d2ec565983d3307c14ec238f9677c
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (4)
raw_fields
{
  "n": 4000000,
  "doi": "10.1038/s41586-023-06812-z",
  "claim": "Yao et al. (2023) reported a whole-brain cell type atlas of adult mouse organized into 34 classes, 338 subclasses, 1,201 supertypes and 5,322 clusters using ~4 million scRNA-seq cells and ~4.3 million MERFISH cells.",
  "title": null,
  "cite_key": "Yao2023",
  "evidence": "Combined scRNA-seq (~4M cells QC) + MERFISH (~4.3M cells) on whole adult mouse brain produced hierarchical taxonomy; Vip GABAergic subclass observed across cortex and other regions, with 5,322 leaf clusters.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "whole adult mouse brain; 10x scRNA-seq + MERFISH",
  "target_section": "section_02",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replicated",
  "_source_cluster_index": 9,
  "claim_source_sentence": "The atlas is hierarchically organized into 4 nested levels of classification: 34 classes, 338 subclasses, 1,201 supertypes and 5,322 clusters."
}
source_refs
[
  "paper:1f98e15e-de06-42f7-9da8-1faa69bba835"
]
evidence_refs
[
  {
    "ref": "paper:1f98e15e-de06-42f7-9da8-1faa69bba835"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

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