- claim_text
Jorstad et al. (2023) identified human-specific L1 interneuron transcriptomic types (e.g., VIP PCDH20 and SST BAGE2) that are homologous to deeper mouse t-types but exhibit no morphologically equivalent neurons in mouse L1, indicating type-specific divergence across species.
- raw_fields
{
"n": null,
"doi": "10.1126/science.adf0805",
"claim": "Jorstad et al. (2023) identified human-specific L1 interneuron transcriptomic types (e.g., VIP PCDH20 and SST BAGE2) that are homologous to deeper mouse t-types but exhibit no morphologically equivalent neurons in mouse L1, indicating type-specific divergence across species.",
"title": null,
"cite_key": "Chartrand2023",
"evidence": "Cross-species Patch-seq comparison of L1 cortical interneurons; human VIP PCDH20 and SST BAGE2 t-types absent from mouse L1; L1 VIP TSPAN12 cells share descending axon collaterals + stellate dendrites + high sag conserved across species.",
"effect_size": null,
"text_access": "fulltext",
"study_system": "human and mouse L1 cortex; Patch-seq + cross-species transcriptomic alignment",
"target_section": "section_02",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replicated",
"_source_cluster_index": 18,
"claim_source_sentence": "No mouse L1 neurons had morphologies resembling the unmatched human L1 t-types (VIP PCDH20 and SST BAGE12, homologous to deeper mouse t-types), and the MC4R subclass was less morphologically distinct, providing evidence for type-specific divergence across species."
}- source_refs
[
"paper:paper-86dac47be132"
]
- source_span
No mouse L1 neurons had morphologies resembling the unmatched human L1 t-types (VIP PCDH20 and SST BAGE12, homologous to deeper mouse t-types), and the MC4R subclass was less morphologically distinct, providing evidence for type-specific divergence across species.
- evidence_refs
[
{
"ref": "paper:paper-86dac47be132"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}