Liu et al. (2021) generated a single-cell DNA methylation atlas of mouse brain…

Details

scope: mouse whole brain; snmC-seq2 single-cell methylome
claim_text: Liu et al. (2021) generated a single-cell DNA methylation atlas of mouse brain identifying CGE-derived Lamp5 and CGE-Vip lineages distinguishable by Bcl11b expression among other markers.
section_id: section_02
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json
review_repo: ComputationalReviewVIP
section_ref: wiki_page:computationalreviewvip-02-classification
source_kind: review_finding
source_path: evidence/section_02_evidence_package.json
source_span: Bcl11b distinguishes OLF-Exc and IT neurons in the excitatory lineage and distinguishes CGE-Lamp5 and CGE-Vip in the inhibitory lineage.
study_system: mouse whole brain; snmC-seq2 single-cell methylome
section_title: Molecular Identity and Transcriptomic Taxonomy
evidence_summary: snmC-seq2 single-cell methylome atlas of 110,294 mouse brain cells; Bcl11b methylation pattern separates CGE-Lamp5 from CGE-Vip lineages, supporting transcriptomic taxonomy at the epigenomic level.
review_bundle_ref: analysis_bundle:ab-2ce40c33e827
replication_status: replicated
review_package_ref: analysis_bundle:ab-2ce40c33e827
source_artifact_ref: wiki_page:computationalreviewvip-02-classification
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_02_evidence_package.json
commit_sha: 95e761177f7d2ec565983d3307c14ec238f9677c
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewVIP

Raw fields (4)

raw_fields

{
  "n": null,
  "doi": "10.1038/s41586-020-03182-8",
  "claim": "Liu et al. (2021) generated a single-cell DNA methylation atlas of mouse brain identifying CGE-derived Lamp5 and CGE-Vip lineages distinguishable by Bcl11b expression among other markers.",
  "title": null,
  "cite_key": "Liu2021",
  "evidence": "snmC-seq2 single-cell methylome atlas of 110,294 mouse brain cells; Bcl11b methylation pattern separates CGE-Lamp5 from CGE-Vip lineages, supporting transcriptomic taxonomy at the epigenomic level.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "mouse whole brain; snmC-seq2 single-cell methylome",
  "target_section": "section_02",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replicated",
  "_source_cluster_index": 14,
  "claim_source_sentence": "Bcl11b distinguishes OLF-Exc and IT neurons in the excitatory lineage and distinguishes CGE-Lamp5 and CGE-Vip in the inhibitory lineage."
}

source_refs

[
  "paper:paper-c79117b43f4e"
]

evidence_refs

[
  {
    "ref": "paper:paper-c79117b43f4e"
  }
]

source_policy

{
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}

Liu et al. (2021) generated a single-cell DNA methylation atlas of mouse brain…

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