NMDAR hypofunction in PV+ interneurons may contribute to schizophrenia symptoms…

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scope: computational models and animal models of schizophrenia
claim_text: NMDAR hypofunction in PV+ interneurons may contribute to schizophrenia symptoms; computational models predict that NMDAR reduction on PV cells decreases gamma oscillation power
section_id: section_10_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-10
source_kind: review_finding
source_path: evidence/section_10_evidence_package.json
source_span: NMDA receptor (NMDAR) hypofunction in Parvalbumin-expressing (PV+) inhibitory neurons (IN) may contribute to symptoms in patients with schizophrenia (SZ).
study_system: computational models and animal models of schizophrenia
section_title: Oscillations and Network Dynamics: Gamma, Ripples, and Synchrony
evidence_summary: NMDAR hypofunction in PV+ interneurons may contribute to schizophrenia symptoms; computational models predict that NMDAR reduction on PV cells decreases gamma oscillation power
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: independently_replicated
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-10
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_10_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1016/j.biopsych.2015.07.005",
  "claim": "NMDAR hypofunction in PV+ interneurons may contribute to schizophrenia symptoms; computational models predict that NMDAR reduction on PV cells decreases gamma oscillation power",
  "evidence": "NMDAR hypofunction in PV+ interneurons may contribute to schizophrenia symptoms; computational models predict that NMDAR reduction on PV cells decreases gamma oscillation power",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "computational models and animal models of schizophrenia",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "NMDA receptor (NMDAR) hypofunction in Parvalbumin-expressing (PV+) inhibitory neurons (IN) may contribute to symptoms in patients with schizophrenia (SZ).",
  "replication_evidence_dois": [
    "10.1038/mp.2011.31"
  ],
  "effect_size_source_sentence": null
}

source_refs

[
  "paper:paper-7f39f00ef933"
]

evidence_refs

[
  {
    "ref": "paper:paper-7f39f00ef933"
  }
]

source_policy

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NMDAR hypofunction in PV+ interneurons may contribute to schizophrenia symptoms…

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