- claim_text
Light-driven activation of fast-spiking interneurons at varied frequencies selectively amplifies gamma oscillations (8-200 Hz range tested), while pyramidal neuron activation amplifies only lower frequency oscillations - a cell-type-specific double dissociation
- raw_fields
{
"n": 0,
"doi": "10.1038/nature08002",
"claim": "Light-driven activation of fast-spiking interneurons at varied frequencies selectively amplifies gamma oscillations (8-200 Hz range tested), while pyramidal neuron activation amplifies only lower frequency oscillations - a cell-type-specific double dissociation",
"evidence": "Light-driven activation of fast-spiking interneurons at varied frequencies selectively amplifies gamma oscillations (8-200 Hz range tested), while pyramidal neuron activation amplifies only lower frequency oscillations - a cell-type-specific double dissociation",
"effect_size": "Sensory input timing relative to gamma cycle determined amplitude and precision of evoked responses",
"text_access": "fulltext",
"study_system": "mouse barrel cortex in vivo, optogenetics",
"replication_status": "independently_replicated",
"claim_source_sentence": "Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8-200 Hz) selectively amplifies gamma oscillations. In contrast, pyramidal neuron activation amplifies only lower frequency oscillations, a cell-type-specific double dissociation.",
"replication_evidence_dois": [
"10.1038/nature07991",
"10.1016/j.neuron.2017.11.033"
],
"effect_size_source_sentence": "We found that the timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses."
}- source_refs
[
"paper:3767f6c5-663b-42ad-bf68-d37f6f00b49d"
]
- source_span
Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8-200 Hz) selectively amplifies gamma oscillations. In contrast, pyramidal neuron activation amplifies only lower frequency oscillations, a cell-type-specific double dissociation.
- evidence_refs
[
{
"ref": "paper:3767f6c5-663b-42ad-bf68-d37f6f00b49d"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}- evidence_summary
Light-driven activation of fast-spiking interneurons at varied frequencies selectively amplifies gamma oscillations (8-200 Hz range tested), while pyramidal neuron activation amplifies only lower frequency oscillations - a cell-type-specific double dissociation