A multi-layer biophysical model of rodent somatosensory cortex incorporating PV…

A multi-layer biophysical model of rodent somatosensory cortex incorporating PV/SOM/VIP interneurons with cell-type-specific short-term plasticity reproduces in vivo population firing-rate data, captures PV/SOM-mediated inhibition and VIP-mediated disinhibition of excitatory cells, and predicts that STP modulates response magnitudes by switching the dominant inhibitory pathway.

{
  "n": null,
  "doi": "10.1093/cercor/bhae378",
  "claim": "A multi-layer biophysical model of rodent somatosensory cortex incorporating PV/SOM/VIP interneurons with cell-type-specific short-term plasticity reproduces in vivo population firing-rate data, captures PV/SOM-mediated inhibition and VIP-mediated disinhibition of excitatory cells, and predicts that STP modulates response magnitudes by switching the dominant inhibitory pathway.",
  "title": null,
  "cite_key": "Jiang2024b",
  "evidence": "Multi-layer microcircuit model fitted to in vivo cell-type-specific firing rates; STP version added to test predictions.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "rodent S1 cortex; biophysical microcircuit modeling",
  "target_section": "section_05",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replication_unknown",
  "_source_cluster_index": 105,
  "claim_source_sentence": "The model reproduces the experimentally observed inhibitory effects of PV and SOM cells and disinhibitory effect of VIP cells on excitatory cells. We further create a version of the model incorporating cell-type-specific short-term synaptic plasticity (STP). While the ongoing activity with and without STP is similar, STP modulates the responses of Exc, SOM, and VIP cells to cell-type-specific stimulation, presumably by changing the dominant inhibitory pathways.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-8797c32e2132"
]

The model reproduces the experimentally observed inhibitory effects of PV and SOM cells and disinhibitory effect of VIP cells on excitatory cells. We further create a version of the model incorporating cell-type-specific short-term synaptic plasticity (STP). While the ongoing activity with and without STP is similar, STP modulates the responses of Exc, SOM, and VIP cells to cell-type-specific stimulation, presumably...

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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