- claim_text
Cadwell et al. (2016) introduced Patch-seq, a method combining whole-cell patch-clamp electrophysiology, single-cell RNA-seq, and morphological characterization on the same neuron, enabling multimodal classification of neuronal cell types in mouse cortex.
- raw_fields
{
"n": 58,
"doi": "10.1038/nbt.3445",
"claim": "Cadwell et al. (2016) introduced Patch-seq, a method combining whole-cell patch-clamp electrophysiology, single-cell RNA-seq, and morphological characterization on the same neuron, enabling multimodal classification of neuronal cell types in mouse cortex.",
"title": null,
"cite_key": "Cadwell2016",
"evidence": "Demonstration on 58 mouse cortical interneurons; transcriptome quality after pipette aspiration sufficient for clustering; correlation of ephys features with transcriptomic identity established workflow used in subsequent VIP MET-type studies.",
"effect_size": null,
"text_access": "fulltext",
"study_system": "mouse cortex; Patch-seq method paper",
"target_section": "section_11",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "single_study",
"_source_cluster_index": 26,
"claim_source_sentence": "To improve the classification of neuronal cell types and the functional characterization of single neurons, we present Patch-seq, a method that combines whole-cell electrophysiological patch-clamp recordings, single-cell RNA-sequencing and morphological characterization."
}- source_refs
[
"paper:paper-1ce98e1d2969"
]
- source_span
To improve the classification of neuronal cell types and the functional characterization of single neurons, we present Patch-seq, a method that combines whole-cell electrophysiological patch-clamp recordings, single-cell RNA-sequencing and morphological characterization.
- evidence_refs
[
{
"ref": "paper:paper-1ce98e1d2969"
}
]- source_policy
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"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
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}- evidence_summary
Demonstration on 58 mouse cortical interneurons; transcriptome quality after pipette aspiration sufficient for clustering; correlation of ephys features with transcriptomic identity established workflow used in subsequent VIP MET-type studies.