In mice transforming a brief whisker cue into delayed licking, secondary whiske…

In mice transforming a brief whisker cue into delayed licking, secondary whisker motor cortex shows enhanced excitation that links sensory processing to lick motor planning, orofacial sensorimotor cortex shows transient suppression that prevents premature licking, and focal sustained activity in frontal cortex during the delay is causally required for licking.

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  "n": 0,
  "doi": "10.1016/j.neuron.2021.05.005",
  "claim": "In mice transforming a brief whisker cue into delayed licking, secondary whisker motor cortex shows enhanced excitation that links sensory processing to lick motor planning, orofacial sensorimotor cortex shows transient suppression that prevents premature licking, and focal sustained activity in frontal cortex during the delay is causally required for licking.",
  "cite_key": "Esmaeili2021",
  "evidence": "Rapid activity evoked by whisker deflection acquired two prominent features for task performance: (1) an enhanced excitation of secondary whisker motor cortex, suggesting its important role connecting whisker sensory processing to lick motor planning; and (2) a transient reduction of activity in orofacial sensorimotor cortex, which contributed to suppressing premature licking.",
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  "text_access": "fulltext",
  "study_system": "mouse cortex-wide; wide-field calcium imaging + multi-region high-density electrophysiology + time-resolved optogenetic manipulation in a whisker-cued delayed-licking task",
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  "replication_status": "single_lab",
  "claim_source_sentence": "Subsequent widespread cortical activity during the delay period largely correlated with anticipatory movements, but when these were accounted for, a focal sustained activity remained in frontal cortex, which was causally essential for licking in the response period.",
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Subsequent widespread cortical activity during the delay period largely correlated with anticipatory movements, but when these were accounted for, a focal sustained activity remained in frontal cortex, which was causally essential for licking in the response period.

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Rapid activity evoked by whisker deflection acquired two prominent features for task performance: (1) an enhanced excitation of secondary whisker motor cortex, suggesting its important role connecting whisker sensory processing to lick motor planning; and (2) a transient reduction of activity in orofacial sensorimotor cortex, which contributed to suppressing premature licking.