- claim_text
Schubert et al. (2024) summarized that mammalian cortex contains ~60 inhibitory transcriptomic types organized into PV, SST, VIP, and Lamp5/Sncg subclasses, with VIP cells primarily targeting other GABAergic subclasses (notably SST) to mediate disinhibition of local pyramidal neurons.
- raw_fields
{
"n": null,
"doi": "10.1007/s00424-024-02923-2",
"claim": "Schubert et al. (2024) summarized that mammalian cortex contains ~60 inhibitory transcriptomic types organized into PV, SST, VIP, and Lamp5/Sncg subclasses, with VIP cells primarily targeting other GABAergic subclasses (notably SST) to mediate disinhibition of local pyramidal neurons.",
"title": null,
"cite_key": "Mao2024",
"evidence": "Multimodal review consolidates current consensus: mouse cortex ~60 inhibitory t-types within 4 subclasses; VIP→SST→PYR disinhibitory motif is canonical; Pvalb-Vipr2 chandelier subtype noted within VIP nomenclature.",
"effect_size": null,
"text_access": "fulltext",
"study_system": "mouse and human cortex (review)",
"target_section": "section_02",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replicated",
"_source_cluster_index": 32,
"claim_source_sentence": "Inhibitory neurons were subdivided into parvalbumin (PV), somatostatin (SST), vasoactive intestinal polypeptide (VIP), and 'other (i.e. Lamp5/Sncg)' subpopulations, which altogether comprise ~60 t-types. The majority of VIP interneurons preferentially target other GABAergic subclasses, notably SST cells, consequently disinhibiting local pyramidal neurons."
}- source_refs
[
"paper:paper-367b1305876d"
]
- source_span
Inhibitory neurons were subdivided into parvalbumin (PV), somatostatin (SST), vasoactive intestinal polypeptide (VIP), and 'other (i.e. Lamp5/Sncg)' subpopulations, which altogether comprise ~60 t-types. The majority of VIP interneurons preferentially target other GABAergic subclasses, notably SST cells, consequently disinhibiting local pyramidal neurons.
- evidence_refs
[
{
"ref": "paper:paper-367b1305876d"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}