The Blue Brain Project CCFv3 augmented atlas (CCFv3_BBP) extends the Allen CCFv…

The Blue Brain Project CCFv3 augmented atlas (CCFv3_BBP) extends the Allen CCFv3 to fully annotate the most rostral and caudal mouse-brain regions (main olfactory bulb, cerebellum, medulla) and provides an improved Nissl reference volume aligned to the new atlas.

{
  "n": 734,
  "doi": "10.1162/imag_a_00565",
  "claim": "The Blue Brain Project CCFv3 augmented atlas (CCFv3_BBP) extends the Allen CCFv3 to fully annotate the most rostral and caudal mouse-brain regions (main olfactory bulb, cerebellum, medulla) and provides an improved Nissl reference volume aligned to the new atlas.",
  "cite_key": "Piluso2025",
  "evidence": "734 Nissl-stained brains aligned to generate a 10-μm average Nissl template; first comprehensive in silico whole-mouse-CNS cell-distribution model built on the enhanced atlas.",
  "effect_size": "734 Nissl brains aligned at 10-μm resolution",
  "text_access": "abstract_only",
  "study_system": "Adult mouse whole brain; CCFv3 augmented atlas + Nissl template at 10 μm",
  "source_cluster_id": "cluster_11",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "To overcome these limitations, we developed the Blue Brain Project (BBP) CCFv3 augmented atlas (CCFv3<sub>BBP</sub>), which includes a fully annotated mouse brain and an improved Nissl-stained reference volume aligned with the CCFv3<sub>BBP</sub>.",
  "replication_evidence_dois": [
    "10.1016/j.cell.2020.04.007",
    "10.1038/s41467-024-53254-w"
  ],
  "effect_size_source_sentence": "This enhanced atlas also features the central nervous system annotation."
}

[
  "paper:paper-3cf435c26092"
]

To overcome these limitations, we developed the Blue Brain Project (BBP) CCFv3 augmented atlas (CCFv3<sub>BBP</sub>), which includes a fully annotated mouse brain and an improved Nissl-stained reference volume aligned with the CCFv3<sub>BBP</sub>.

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  "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b",
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