- claim_text
Two-photon optogenetic activation of single VIP interneurons in mouse V1 in vivo combined with calcium imaging showed that VIP cells have narrow axons that inhibit nearby SST interneurons, which then disinhibit pyramidal cells — supporting a focal, 'spotlight-of-attention' lateral disinhibition mechanism rather than spatially diffuse VIP signaling.
- raw_fields
{
"n": null,
"doi": "10.1523/jneurosci.3646-15.2016",
"claim": "Two-photon optogenetic activation of single VIP interneurons in mouse V1 in vivo combined with calcium imaging showed that VIP cells have narrow axons that inhibit nearby SST interneurons, which then disinhibit pyramidal cells — supporting a focal, 'spotlight-of-attention' lateral disinhibition mechanism rather than spatially diffuse VIP signaling.",
"title": null,
"cite_key": "Karnani2016b",
"evidence": "Two-photon single-cell optogenetic activation + 2-photon Ca2+ imaging of VIP→SST→Pyr microcircuit in mouse V1 in vivo.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "mouse V1 in vivo 2-photon optogenetics + imaging",
"target_section": "section_05",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "single_study",
"_source_cluster_index": 84,
"claim_source_sentence": "We find that VIP interneurons have narrow axons and inhibit nearby somatostatin interneurons, which themselves inhibit pyramidal cells."
}- source_refs
[
"paper:paper-0a3cf7627c63"
]
- evidence_refs
[
{
"ref": "paper:paper-0a3cf7627c63"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}