- claim_text
Patch-seq electrophysiological 'subthreshold-2' principal component is highly correlated with input resistance (Pearson r = 0.90), and a separate 'subthreshold (normalized) 1' PC reflects sag amplitude during hyperpolarizing current — providing two orthogonal axes of intrinsic-property variation that can be regressed onto t-type identity.
- raw_fields
{
"n": 4270,
"doi": "10.1016/j.cell.2020.09.057",
"claim": "Patch-seq electrophysiological 'subthreshold-2' principal component is highly correlated with input resistance (Pearson r = 0.90), and a separate 'subthreshold (normalized) 1' PC reflects sag amplitude during hyperpolarizing current — providing two orthogonal axes of intrinsic-property variation that can be regressed onto t-type identity.",
"title": null,
"cite_key": "Gouwens2020a",
"evidence": "PCA over 4,200+ Patch-seq cells; principal-component-vs-feature correlations across all neurons (excitatory + inhibitory).",
"effect_size": "sPC2 ↔ Rin: r = 0.90 (Pearson); sPC1(norm) ↔ sag",
"text_access": "fulltext",
"study_system": "mouse VISp Patch-seq",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replication_unknown",
"_source_cluster_index": 28,
"claim_source_sentence": "Many of the sPCs were strongly related to traditional electrophysiological features; for example, the “subthreshold 2” sPC was correlated with input resistance (Pearson’s r = 0.90), and the “subthreshold (normalized) 1” sPC reflected the amount of sag induced by hyperpolarizing current steps (lower ...).",
"replication_evidence_dois": [],
"effect_size_source_sentence": "the “subthreshold 2” sPC was correlated with input resistance (Pearson’s r = 0.90)"
}- source_refs
[
"paper:paper-pm-33186530"
]
- source_span
Many of the sPCs were strongly related to traditional electrophysiological features; for example, the “subthreshold 2” sPC was correlated with input resistance (Pearson’s r = 0.90), and the “subthreshold (normalized) 1” sPC reflected the amount of sag induced by hyperpolarizing current steps (lower ...).
- evidence_refs
[
{
"ref": "paper:paper-pm-33186530"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}