Hippocampal interneurons are produced in two distinct neurogenic waves — MGE be…

Hippocampal interneurons are produced in two distinct neurogenic waves — MGE between E9–E12 and CGE between E12–E16 — and invade the hippocampus by E14; in the mature hippocampus, CGE-derived interneurons preferentially populate strata lacunosum moleculare and deep radiatum (CCK+, calretinin+, VIP+, reelin+ subtypes), while MGE-derived populations dominate strata pyramidale and oriens (parvalbumin+, somatostatin+).

{
  "n": null,
  "doi": "10.1523/jneurosci.0323-11.2011",
  "claim": "Hippocampal interneurons are produced in two distinct neurogenic waves — MGE between E9–E12 and CGE between E12–E16 — and invade the hippocampus by E14; in the mature hippocampus, CGE-derived interneurons preferentially populate strata lacunosum moleculare and deep radiatum (CCK+, calretinin+, VIP+, reelin+ subtypes), while MGE-derived populations dominate strata pyramidale and oriens (parvalbumin+, somatostatin+).",
  "title": null,
  "cite_key": "Tricoire2011",
  "evidence": "Abstract: combined molecular, anatomical, and electrophysiological characterization in MGE- and CGE-specific transgenic and inducible mouse lines.",
  "effect_size": "MGE wave E9–E12; CGE wave E12–E16; invasion by E14",
  "figure_data": [
    {
      "type": "developmental_timing",
      "unit": "embryonic day (mouse)",
      "metric": "MGE neurogenic wave",
      "source": "Abstract",
      "value_max": "E12",
      "value_min": "E9"
    },
    {
      "type": "developmental_timing",
      "unit": "embryonic day (mouse)",
      "metric": "CGE neurogenic wave",
      "source": "Abstract",
      "value_max": "E16",
      "value_min": "E12"
    }
  ],
  "text_access": "abstract_only",
  "study_system": "mouse hippocampus, transgenic and inducible MGE/CGE reporter mice",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "replicated",
  "_source_cluster_index": 13,
  "claim_source_sentence": "We found that hippocampal interneurons are produced in two neurogenic waves between E9-E12 and E12-E16 from MGE and CGE, respectively, and invade the hippocampus by E14.",
  "replication_evidence_dois": [
    "10.1523/jneurosci.5123-09.2010"
  ],
  "effect_size_source_sentence": null
}

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