- claim_text
Fast-spiking interneurons in human neocortex possess axon-initial-segment (AIS) adaptations distinct from rodent FS-INs, including altered AIS length and Na+/K+ channel composition, contributing to species-specific high-frequency firing properties—evidence that the canonical 'PV-FS-IN' molecular class has structural divergence between mouse and human despite transcriptomic homology.
- raw_fields
{
"n": null,
"doi": "10.1371/journal.pbio.3003549",
"claim": "Fast-spiking interneurons in human neocortex possess axon-initial-segment (AIS) adaptations distinct from rodent FS-INs, including altered AIS length and Na+/K+ channel composition, contributing to species-specific high-frequency firing properties—evidence that the canonical 'PV-FS-IN' molecular class has structural divergence between mouse and human despite transcriptomic homology.",
"title": null,
"cite_key": "Bakos2025",
"evidence": "Human neurosurgical specimens + IHC of AIS markers + correlated electrophysiology; comparison to rodent FS-INs.",
"effect_size": null,
"text_access": "abstract_only",
"study_system": "human + rodent neocortex; AIS structural/functional comparison",
"target_section": "section_11",
"_source_cluster": "cluster_01_molecular_taxonomy",
"replication_status": "replication_unknown",
"_source_cluster_index": 125,
"claim_source_sentence": "Adaptations of the axon initial segment in fast-spiking interneurons of the human neocortex.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-7f008ed47247"
]
- evidence_refs
[
{
"ref": "paper:paper-7f008ed47247"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}