- raw_fields
{
"n": 3000,
"doi": "10.1371/journal.pcbi.1012259",
"claim": "Morphological alterations in Down syndrome PV neurons directly reduce gamma oscillation power (~40 Hz) in a connectivity-constrained cortical network model",
"evidence": "3000-neuron cortical network model with morphology-derived connectivity for WT, TgDyrk1A, Ts65Dn mice",
"effect_size": "gamma activity ~40 Hz diminished in DS models",
"text_access": "fulltext",
"study_system": "mouse motor cortex cross-sectional layer model, 3000 neurons, WT/TgDyrk1A/Ts65Dn",
"replication_status": "replication_unknown",
"claim_source_sentence": "Our findings reveal a dynamic interplay between pyramidal and fast-spiking interneurons leading to the emergence of gamma activity (∼40 Hz). In the DS models this gamma activity is diminished, corroborating experimental observations and validating our computational methodology.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Our findings reveal a dynamic interplay between pyramidal and fast-spiking interneurons leading to the emergence of gamma activity (∼40 Hz). In the DS models this gamma activity is diminished."
}- source_refs
[
"paper:paper-80c3155dbabc"
]
- source_span
Our findings reveal a dynamic interplay between pyramidal and fast-spiking interneurons leading to the emergence of gamma activity (∼40 Hz). In the DS models this gamma activity is diminished, corroborating experimental observations and validating our computational methodology.
- evidence_refs
[
{
"ref": "paper:paper-80c3155dbabc"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}