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All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

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30 results

Gap How does TGM2 mechanistically regulate ER-mitochondria contact sites in neuronal cells? rel 0.30

mitochondria contacts affecting calcium homeostasis, but the specific molecular mechanisms

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Gap How do transferred mitochondria integrate functionally with recipient neuron bioenergetics without disrupting cellular homeostasis? rel 0.20

mitochondria avoid triggering innate immune responses or metabolic disruption in recipient

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Gap How do non-energetic mitochondrial functions contribute to ASD beyond impaired ATP production? rel 0.20

mitochondria have functions beyond aerobic energy production (referencing Ca regulation

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Gap Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondrial depletion in tauopathy? rel 0.20

mitochondria removal, actually depletes healthy mitochondria from synapses in tauopathy

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Gap Why does α-synuclein specifically accumulate in ER and mitochondria rather than cytoplasm in DNAJC6 deficiency? rel 0.20

mitochondria following DNAJC6 paucity, but doesn't explain the organelle

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Gap Do transferred mitochondria from diseased astrocytes carry pathological damage that could harm recipient neurons? rel 0.20

mitochondria from AD or other neurodegenerative disease contexts retain dysfunction

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Gap How does HTT selectively recruit different mitophagy receptors to damaged versus healthy mitochondria? rel 0.20

mitochondria requiring clearance from functional ones. This selectivity mechanism is crucial

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Gap What are the stepwise biological mechanisms of αSyn misimport into mitochondria and subsequent aggregation? rel 0.20

mitochondria-mediated apoptosis, remain unknown. Understanding these mechanisms is critical

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Gap How does SERCA2-TSPO-MCU coupling at MAMs specifically drive osteogenic transdifferentiation in VSMCs? rel 0.20

mitochondria-ER contact sites linked to vascular calcification but doesn

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Gap What are the molecular mechanisms by which transplanted mitochondria integrate and function in recipient dopaminergic neurons? rel 0.20

mitochondria are taken up, integrated into cellular networks, or maintain

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Gap What are the specific molecular mechanisms by which PINK1/Parkin modulate Ca2+ signaling at ER-mitochondria contacts? rel 0.20

mitochondria contact sites and modulate Ca2+ signaling, but the precise

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Gap How do alterations in ER-mitochondria tethering causally contribute to neurodegeneration across different diseases? rel 0.20

mitochondria tethering is a common hallmark of many neurodegenerative diseases

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Gap How does anterograde transport of damaged mitochondria contribute to distal axon vulnerability? rel 0.20

mitochondria moving anterogradely and accumulating in distal axons, but the mechanisms

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Gap Why do transferred mitochondria cause oxidative damage despite being metabolically active organelles? rel 0.20

mitochondria accumulate reactive oxygen species leading to recipient cell damage

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Gap What is the therapeutic window and dosing strategy for urolithin A in preventing diabetes-induced amyloidogenesis? rel 0.10

mitochondria contacts and calcium homeostasis. (2021, Cell Death Differ, PMID

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Gap How do organelle-specific selective autophagy pathways differentially contribute to neuronal survival? rel 0.10

mitochondria, ER, ribosomes, etc.), it's unclear how dysfunction in specific

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Gap What are the molecular determinants that control directional mitochondrial transfer from astrocytes to neurons? rel 0.10

mitochondria. Understanding these mechanisms is essential for therapeutic targeting. Source

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Gap What molecular mechanisms drive excessive ROS generation when mitochondrial genomes are incompatible? rel 0.10

mitochondria accumulate reactive oxygen species leading to recipient cell damage

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Gap How do Aβ and tau differentially trigger mitochondrial DNA release to activate cGAS-STING signaling? rel 0.10

mitochondria and triggers DNA leakage remain undefined. This mechanistic gap prevents

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Gap How does Parkin regulate mitochondrial biogenesis alongside its established role in mitophagy? rel 0.10

mitochondria represents a poorly understood aspect of mitochondrial quality control

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Gap How do therapeutic agents targeting VAPB-PTPIP51 achieve selectivity without disrupting normal MAM function? rel 0.10

mitochondria tethering complex VAPB-PTPIP51: Novel therapeutic targets for aging

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Gap What triggers irreversible SERCA2 Cys oxidation in the context of vascular calcification? rel 0.10

Mitochondria-Associated Endoplasmic Reticulum Membranes. (2026, Pharmacol Res, PMID:41932666)

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Gap What determines the cell-type specificity of ABCA7 variant effects despite widespread expression? rel 0.10

impact phosphatidylcholine and mitochondria in neurons. (2025, Nature, PMID:40931065)

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Gap How does disrupted phosphatidylcholine metabolism mechanistically link to impaired DNA repair in ABCA7 variants? rel 0.10

impact phosphatidylcholine and mitochondria in neurons. (2025, Nature, PMID:40931065)

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Gap How do gC1qR surface expression levels affect microglial C1q signaling in neurodegeneration? rel 0.10

mitochondria remains poorly characterized. Understanding this regulation could identify new intervention

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Gap Why does mitochondrial oxidation increase despite reduced mitochondrial calcium in MCU knockout mice? rel 0.10

mitochondria interactions. Gap type: contradiction Source paper: Cytosolic calcium regulates

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Gap What molecular mechanism causes >94% of PD patients to fail Miro1 removal from depolarized mitochondria? rel 0.10

The abstract reports a striking near-universal defect in Miro1

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Gap What determines TFAM's selectivity for cytoplasmic versus mitochondrial mtDNA binding? rel 0.10

mitochondria but this study reveals it binds cytoplasmic mtDNA as an autophagy

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Gap What specific mechanisms link mitochondrial electron transport chain dysfunction to ASD pathophysiology? rel 0.10

role of mitochondria in autism spectrum disorder. (None, None, PMID:39223276)

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Gap How do multiple pathological mechanisms (ammonia, manganese, autophagy, mitochondria) interact synergistically in HE? rel 0.10

The abstract acknowledges that HE occurs under 'synergistic effect of

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