Single-cell-initiated monosynaptic rabies tracing combined with GCaMP6s imaging…

Single-cell-initiated monosynaptic rabies tracing combined with GCaMP6s imaging in mouse V1 reveals that the presynaptic inputs of an individual L2/3 pyramidal neuron form layer-specific functional modules in which neurons within a layer share similar direction preferences; in one-third of networks the layer modules are locked to the postsynaptic neuron's preferred direction.

{
  "n": null,
  "doi": "10.1126/science.aab1687",
  "claim": "Single-cell-initiated monosynaptic rabies tracing combined with GCaMP6s imaging in mouse V1 reveals that the presynaptic inputs of an individual L2/3 pyramidal neuron form layer-specific functional modules in which neurons within a layer share similar direction preferences; in one-third of networks the layer modules are locked to the postsynaptic neuron's preferred direction.",
  "cite_key": "Wertz2015",
  "evidence": "Single-cell-initiated, monosynaptically restricted retrograde transsynaptic rabies tracing with GCaMP6s and two-photon imaging of motion-evoked activity of individual L2/3 pyramidal cells and their inputs across layers in mouse V1.",
  "effect_size": null,
  "text_access": "abstract_only",
  "study_system": "mouse V1 L2/3 pyramidal neurons and their presynaptic networks across layers",
  "argument_role": "supporting",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Neurons within each layer exhibited similar motion direction preferences, forming layer-specific functional modules. In one-third of the networks, the layer modules were locked to the direction preference of the postsynaptic neuron, whereas for other networks the direction preference varied by layer.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-39dfc6d6e34c"
]

Neurons within each layer exhibited similar motion direction preferences, forming layer-specific functional modules. In one-third of the networks, the layer modules were locked to the direction preference of the postsynaptic neuron, whereas for other networks the direction preference varied by layer.

[
  {
    "ref": "paper:paper-39dfc6d6e34c"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}