snRNA-seq of >2.4 million cells across 18 locations of common marmoset brain sh…

snRNA-seq of >2.4 million cells across 18 locations of common marmoset brain shows that adult transcriptomic identity of neurons is shaped more by developmental origin than by neurotransmitter repertoire. smFISH mapping reveals that lateral prefrontal and higher-order association cortices are distinguished by HIGH proportions of VIP+ neurons relative to other cortical areas, identifying a primate-specific regional enrichment of VIP+ INs in association cortex.

{
  "n": null,
  "doi": "10.1126/sciadv.adk3986",
  "claim": "snRNA-seq of >2.4 million cells across 18 locations of common marmoset brain shows that adult transcriptomic identity of neurons is shaped more by developmental origin than by neurotransmitter repertoire. smFISH mapping reveals that lateral prefrontal and higher-order association cortices are distinguished by HIGH proportions of VIP+ neurons relative to other cortical areas, identifying a primate-specific regional enrichment of VIP+ INs in association cortex.",
  "title": null,
  "cite_key": "Krienen2023",
  "evidence": "Sci Adv 2024. Method: snRNA-seq of marmoset brain (18 regions, >2.4M cells); smFISH mapping; AAV-GFP enhancers.",
  "effect_size": null,
  "figure_data": null,
  "text_access": "abstract_only",
  "key_entities": [
    "marmoset",
    "primate",
    "snRNA-seq",
    "VIP",
    "prefrontal",
    "association cortex",
    "smFISH",
    "striatum",
    "neocortex",
    "developmental origin"
  ],
  "study_system": "common marmoset (Callithrix jacchus) adult brain (18 regions)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single_study",
  "_source_cluster_index": 145,
  "claim_source_sentence": "The adult transcriptomic identity of most neuronal types is shaped more by developmental origin than by neurotransmitter signaling repertoire. Quantitative mapping of GABAergic types with single-molecule FISH (smFISH) reveals that interneurons in the striatum and neocortex follow distinct spatial principles, and that lateral prefrontal and other higher-order cortical association areas are distinguished by high proportions of VIP+ neurons.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

[
  "paper:paper-558d3e24c74b"
]

The adult transcriptomic identity of most neuronal types is shaped more by developmental origin than by neurotransmitter signaling repertoire. Quantitative mapping of GABAergic types with single-molecule FISH (smFISH) reveals that interneurons in the striatum and neocortex follow distinct spatial principles, and that lateral prefrontal and other higher-order cortical association areas are distinguished by high propo...

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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