Comprehensive scRNA-seq of mouse telencephalon (611,423 adult + 614,569 prenata…

Comprehensive scRNA-seq of mouse telencephalon (611,423 adult + 614,569 prenatal–postnatal cells from E7 to P14) yields a hierarchical GABAergic cell-type taxonomy of 7 classes, 52 subclasses, 284 supertypes and 1,051 adult clusters (1,688 developmental clusters). Long-distance migration and dispersion is common across nearly ALL classes of telencephalic GABAergic neurons. Cortical, striatal and some pallidal GABAergic neurons undergo extensive POSTNATAL diversification, whereas septal, preoptic and most pallidal types emerge in an embryonic burst with limited postnatal diversification.

{
  "n": null,
  "doi": "10.1038/s41586-025-09296-1",
  "claim": "Comprehensive scRNA-seq of mouse telencephalon (611,423 adult + 614,569 prenatal–postnatal cells from E7 to P14) yields a hierarchical GABAergic cell-type taxonomy of 7 classes, 52 subclasses, 284 supertypes and 1,051 adult clusters (1,688 developmental clusters). Long-distance migration and dispersion is common across nearly ALL classes of telencephalic GABAergic neurons. Cortical, striatal and some pallidal GABAergic neurons undergo extensive POSTNATAL diversification, whereas septal, preoptic and most pallidal types emerge in an embryonic burst with limited postnatal diversification.",
  "title": null,
  "cite_key": "Vanvelthoven2025",
  "evidence": "Nature 2025 Allen Institute. Method: scRNA-seq of mouse telencephalon, E7 → P14 + young adult; 1.2M cells total.",
  "effect_size": null,
  "figure_data": null,
  "text_access": "abstract_only",
  "key_entities": [
    "scRNA-seq",
    "telencephalon",
    "GABAergic taxonomy",
    "postnatal diversification",
    "cortex",
    "striatum",
    "septum",
    "preoptic",
    "mouse",
    "Allen"
  ],
  "study_system": "mouse telencephalon E7 → adult (>1.2M cells)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single_study",
  "_source_cluster_index": 149,
  "claim_source_sentence": "We present a hierarchically organized adult telencephalic GABAergic neuronal cell-type taxonomy of 7 classes, 52 subclasses, 284 supertypes and 1,051 clusters, as well as a corresponding developmental taxonomy of 1,688 clusters across ages from embryonic day 7 to postnatal day 14. ... Transcriptomically and developmentally related cell types are often found in distant and diverse brain regions, indicating that long-distance migration and dispersion is a common characteristic of nearly all classes of telencephalic GABAergic neurons. ... cortical, striatal and some pallidal GABAergic neurons undergo extensive postnatal diversification, whereas septal, preoptic and most pallidal GABAergic neuronal types emerge in a burst during the embryonic stage with limited postnatal diversification.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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We present a hierarchically organized adult telencephalic GABAergic neuronal cell-type taxonomy of 7 classes, 52 subclasses, 284 supertypes and 1,051 clusters, as well as a corresponding developmental taxonomy of 1,688 clusters across ages from embryonic day 7 to postnatal day 14. ... Transcriptomically and developmentally related cell types are often found in distant and diverse brain regions, indicating that long-...

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