The fast-spiking phenotype is defined by brief action potentials with large and…

The fast-spiking phenotype is defined by brief action potentials with large and fast afterhyperpolarizations, the ability to sustain high-frequency firing with little spike-frequency adaptation, low input resistance, and fast membrane time constant, and is almost exclusively associated with PV-expressing interneurons.

{
  "n": 0,
  "doi": "10.1016/j.neuron.2016.06.033",
  "claim": "The fast-spiking phenotype is defined by brief action potentials with large and fast afterhyperpolarizations, the ability to sustain high-frequency firing with little spike-frequency adaptation, low input resistance, and fast membrane time constant, and is almost exclusively associated with PV-expressing interneurons.",
  "evidence": "Comprehensive review synthesizing decades of electrophysiological characterization of cortical GABAergic interneurons, establishing the cardinal features of the FS phenotype.",
  "effect_size": "FS phenotype features: brief APs, large fast AHPs, minimal adaptation, low Rin, fast tau_m",
  "text_access": "fulltext",
  "study_system": "neocortical GABAergic interneurons (review)",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "PV cells display brief action potentials with large and fast afterhyperpolarizations, can sustain high-frequency firing with little spike-frequency adaptation, and have low input resistance and fast membrane time constant.",
  "replication_evidence_dois": [
    "10.1152/physrev.00007.2017"
  ],
  "effect_size_source_sentence": "PV cells display brief action potentials with large and fast afterhyperpolarizations, can sustain high-frequency firing with little spike-frequency adaptation, and have low input resistance and fast membrane time constant."
}

[
  "paper:paper-53c8505de50f"
]

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  {
    "ref": "paper:paper-53c8505de50f"
  }
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  "notes": [
    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}