Single-cell RNA-seq of 23,822 mouse neocortical cells from primary visual corte…

Single-cell RNA-seq of 23,822 mouse neocortical cells from primary visual cortex and anterior lateral motor cortex defined 133 transcriptomic types; most glutamatergic types were area-specific while most GABAergic types were shared, and types were mapped to long-range projection specificity via retrograde labeling.

{
  "n": 23822,
  "doi": "10.1038/s41586-018-0654-5",
  "claim": "Single-cell RNA-seq of 23,822 mouse neocortical cells from primary visual cortex and anterior lateral motor cortex defined 133 transcriptomic types; most glutamatergic types were area-specific while most GABAergic types were shared, and types were mapped to long-range projection specificity via retrograde labeling.",
  "cite_key": "Tasic2018",
  "evidence": "Deep, single-cell RNA sequencing combined with retrograde projection labeling in mouse VISp and ALM.",
  "effect_size": "23,822 cells; 133 transcriptomic types; nearly all GABAergic types shared vs glutamatergic types area-specific",
  "text_access": "abstract_only",
  "study_system": "adult mouse primary visual cortex (VISp) and anterior lateral motor cortex (ALM)",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "To investigate the diversity of cell types across the mouse neocortex, here we analysed 23,822 cells from two areas at distant poles of the mouse neocortex: the primary visual cortex and the anterior lateral motor cortex.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/s41586-021-03950-0",
    "10.1038/s41586-021-03500-8"
  ],
  "effect_size_source_sentence": "We define 133 transcriptomic cell types by deep, single-cell RNA sequencing."
}

[
  "paper:paper-pm-30382198"
]

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