The BICCN multimodal census of mammalian primary motor cortex integrates single…

The BICCN multimodal census of mammalian primary motor cortex integrates single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved transcriptomes, morpho-electrophysiology and cellular-resolution input-output mapping into a cross-species consensus taxonomy of cortical cell types.

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  "doi": "10.1038/s41586-021-03950-0",
  "claim": "The BICCN multimodal census of mammalian primary motor cortex integrates single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved transcriptomes, morpho-electrophysiology and cellular-resolution input-output mapping into a cross-species consensus taxonomy of cortical cell types.",
  "cite_key": "BRAINInitiativeCellCensusNetworkBICCN2021",
  "evidence": "Coordinated multi-modal profiling and integration of single-cell genomics, MERFISH, Patch-seq, single-neuron reconstruction and viral connectomics in mouse M1 and homologous regions of marmoset and human.",
  "effect_size": "qualitative — unified multimodal taxonomy",
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  "study_system": "mouse, marmoset, human primary motor cortex (BICCN)",
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This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input-output mapping, integrated through cross-modal computational analysis.

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