Details
- scope
- freely-moving D1-Cre and A2A-Cre mice, GCaMP3 fibre photometry, dorsal striatum
- claim_text
- In vivo calcium imaging of D1- and A2A-expressing SPNs revealed concurrent — not opposing — activation of direct- and indirect-pathway neurons during action initiation, challenging the strict opposing-pathway dichotomy.
- section_id
- section_04
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
- effect_size
- concurrent rises in both pathways predicted contraversive movements within 500 ms
- review_repo
- ComputationalReviewLoops
- section_ref
- wiki_page:computationalreviewloops-04
- source_kind
- review_finding
- source_path
- evidence/section_04_evidence_package.json
- source_span
- The onset of GCAMP3 fluorescence transients in both pathways preceded movement onset.
- study_system
- freely-moving D1-Cre and A2A-Cre mice, GCaMP3 fibre photometry, dorsal striatum
- section_title
- Striatal Output Pathways: Direct, Indirect, and Beyond
- evidence_summary
- review_bundle_ref
- analysis_bundle:ab-d49e54403ef9
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-d49e54403ef9
- source_artifact_ref
- wiki_page:computationalreviewloops-04
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops/blob/0632aae8abc141909207fe91f6349b9e36489c3b/evidence/section_04_evidence_package.json
- commit_sha
- 0632aae8abc141909207fe91f6349b9e36489c3b
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewLoops
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1038/nature11846", "claim": "In vivo calcium imaging of D1- and A2A-expressing SPNs revealed concurrent — not opposing — activation of direct- and indirect-pathway neurons during action initiation, challenging the strict opposing-pathway dichotomy.", "cite_key": "Cui2013", "evidence": "", "effect_size": "concurrent rises in both pathways predicted contraversive movements within 500 ms", "text_access": "fulltext", "study_system": "freely-moving D1-Cre and A2A-Cre mice, GCaMP3 fibre photometry, dorsal striatum", "source_cluster_id": "cluster_04", "replication_status": "independently_replicated", "claim_source_sentence": "The onset of GCAMP3 fluorescence transients in both pathways preceded movement onset.", "replication_evidence_dois": [ "10.1016/j.cell.2016.06.032", "10.1016/j.neuron.2017.08.015", "10.1016/j.cell.2018.04.019" ], "effect_size_source_sentence": "Concurrent activation of SPNs from both pathways in one hemisphere preceded the initiation of contraversive movements and predicted the occurrence of specific movements within 500 ms." }- source_refs
[ "paper:paper-10_1038_nature11846" ]
- evidence_refs
[ { "ref": "paper:paper-10_1038_nature11846" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "0632aae8abc141909207fe91f6349b9e36489c3b", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewLoops" }