Targeted two-photon photostimulation of small groups of mouse motor cortex neur…

Targeted two-photon photostimulation of small groups of mouse motor cortex neurons during a memory-guided response task produces sparse responses in coupled neurons over ~100 μm, with neurons of similar task selectivity preferentially coupled, and stimulus-evoked activity in stimulated and coupled neurons persists for seconds — far outlasting the photostimulus — producing predictable behavioural biases.

{
  "n": 0,
  "doi": "10.1038/s41593-020-00776-3",
  "claim": "Targeted two-photon photostimulation of small groups of mouse motor cortex neurons during a memory-guided response task produces sparse responses in coupled neurons over ~100 μm, with neurons of similar task selectivity preferentially coupled, and stimulus-evoked activity in stimulated and coupled neurons persists for seconds — far outlasting the photostimulus — producing predictable behavioural biases.",
  "cite_key": "Daie2021",
  "evidence": "",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "mouse motor cortex (ALM); two-photon imaging + targeted two-photon photostimulation during memory-guided response task",
  "argument_role": "supporting",
  "replication_status": "single_lab",
  "claim_source_sentence": "Targeted two-photon photostimulation of small (<10) groups of neurons produced sparse calcium responses in coupled neurons over approximately 100&#x2009;&#x3bc;m.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Responses of stimulated and coupled neurons persisted for seconds, far outlasting the duration of the photostimuli."
}

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