Channelrhodopsin-assisted circuit mapping in mouse cortex shows that L2/3-to-L5…

Channelrhodopsin-assisted circuit mapping in mouse cortex shows that L2/3-to-L5 projections — both within hemisphere and via the corpus callosum — are stronger than L2/3-to-L2/3, indicating shared laminar logic for local and long-range excitatory output.

{
  "n": 0,
  "doi": "10.1038/nn1891",
  "claim": "Channelrhodopsin-assisted circuit mapping in mouse cortex shows that L2/3-to-L5 projections — both within hemisphere and via the corpus callosum — are stronger than L2/3-to-L2/3, indicating shared laminar logic for local and long-range excitatory output.",
  "cite_key": "Petreanu2007",
  "evidence": "ChR2-assisted circuit mapping (CRACM) in slices of mouse somatosensory cortex with callosal axons expressing ChR2; photostimulation paired with whole-cell recording.",
  "effect_size": "L2/3→L5 stronger than L2/3→L2/3 in both ipsi- and contralateral cortex",
  "text_access": "abstract_only",
  "study_system": "mouse somatosensory cortex; CRACM/optogenetic circuit mapping of callosal L2/3 projections",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "In both hemispheres the L2/3-to-L5 projection is stronger than the L2/3-to-L2/3 projection.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1093/cercor/bhab325",
    "10.1016/j.neuron.2018.12.005"
  ],
  "effect_size_source_sentence": "In both hemispheres the L2/3-to-L5 projection is stronger than the L2/3-to-L2/3 projection."
}

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