Multipatch and 2-photon optogenetic characterization of mouse V1 finds connecti…

Multipatch and 2-photon optogenetic characterization of mouse V1 finds connections between excitatory cell classes and layers are sparse but present, with most mouse pyramidal–pyramidal synapses showing short-term depression and a L2/3 subset displaying facilitation.

{
  "n": 0,
  "doi": "10.7554/elife.37349",
  "claim": "Multipatch and 2-photon optogenetic characterization of mouse V1 finds connections between excitatory cell classes and layers are sparse but present, with most mouse pyramidal–pyramidal synapses showing short-term depression and a L2/3 subset displaying facilitation.",
  "cite_key": "Seeman2018",
  "evidence": "Multipatch electrophysiology supplemented with two-photon optogenetics in adult mouse V1 slices; intralaminar excitatory–excitatory connectivity and short-term plasticity quantified.",
  "effect_size": "Sparse but uniform intralaminar E→E connectivity across layers; majority depressing, L2/3 subset facilitating",
  "text_access": "abstract_only",
  "study_system": "adult mouse V1 (slice); multipatch electrophysiology with two-photon optogenetic supplementation",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We find that connections are sparse but present among all excitatory cell classes and layers we sampled, and that most mouse synapses exhibited short-term depression with similar dynamics.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1016/j.xinn.2024.100735",
    "10.7554/eLife.71103"
  ],
  "effect_size_source_sentence": "Synaptic signaling between a subset of layer 2/3 neurons, however, exhibited facilitation."
}

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]

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