- claim_text
Scn1a haploinsufficiency causes substantial, persistent reduction of excitability in both fast-spiking parvalbumin-expressing and somatostatin-expressing cortical interneurons, while excitatory neurons are unaffected, in a Dravet syndrome mouse model.
- raw_fields
{
"n": 0,
"doi": "10.1073/pnas.1411131111",
"claim": "Scn1a haploinsufficiency causes substantial, persistent reduction of excitability in both fast-spiking parvalbumin-expressing and somatostatin-expressing cortical interneurons, while excitatory neurons are unaffected, in a Dravet syndrome mouse model.",
"evidence": "Whole-cell recordings in Scn1a+/- mice showed reduced excitability in both PV and SST interneurons but not in excitatory neurons, providing the physiological basis for Dravet syndrome.",
"effect_size": "substantial reduction of excitability in both PV-FS and SST interneurons; excitatory neurons unaffected",
"text_access": "fulltext",
"study_system": "mouse cortex, Scn1a+/- Dravet syndrome model",
"replication_status": "independently_replicated",
"claim_source_sentence": "Our results show that two major types of inhibitory neurons are impaired in generation of electrical signals by a DS mutation, whereas excitatory neurons are unaffected.",
"replication_evidence_dois": [
"10.1523/jneurosci.5270-06.2007"
],
"effect_size_source_sentence": "Our results show that two major types of inhibitory neurons are impaired in generation of electrical signals by a DS mutation, whereas excitatory neurons are unaffected."
}- source_refs
[
"paper:paper-855d0bdbad3b"
]
- evidence_refs
[
{
"ref": "paper:paper-855d0bdbad3b"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}