Pathway-specific optogenetic silencing (eOPN3) of axons projecting to mouse whi…

Pathway-specific optogenetic silencing (eOPN3) of axons projecting to mouse whisker primary somatosensory barrel cortex (wS1) during whisking shows that inhibition of whisker primary motor cortex (wM1) inputs does not affect wS1 spike rates or membrane potential during whisking, whereas inhibition of axons from whisker-related secondary motor / thalamic inputs alters the depolarization and slow-wave reduction during whisking — direct interareal causal dissection of the cortical inputs that carry motor-related signals into sensory cortex.

{
  "n": 0,
  "doi": "10.1523/jneurosci.1148-23.2023",
  "claim": "Pathway-specific optogenetic silencing (eOPN3) of axons projecting to mouse whisker primary somatosensory barrel cortex (wS1) during whisking shows that inhibition of whisker primary motor cortex (wM1) inputs does not affect wS1 spike rates or membrane potential during whisking, whereas inhibition of axons from whisker-related secondary motor / thalamic inputs alters the depolarization and slow-wave reduction during whisking — direct interareal causal dissection of the cortical inputs that carry motor-related signals into sensory cortex.",
  "cite_key": "Kawatani2024",
  "evidence": "Spontaneous whisking in air induced the changes in spike rates of a subset of wS1 neurons, which were accompanied by depolarization and substantial reduction of slow-wave oscillatory fluctuations of membrane potential.",
  "effect_size": "",
  "text_access": "fulltext",
  "study_system": "mouse whisker primary somatosensory cortex (wS1); presynaptic-specific optogenetic silencing of long-range inputs (wM1 and others) + whole-cell recording during whisking",
  "argument_role": "supporting",
  "replication_status": "single_lab",
  "claim_source_sentence": "Inhibition of inputs from the whisker primary motor cortex (wM1) to wS1 did not alter the spike rates and dynamics of wS1 neurons during whisking.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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