Details
- scope
- mouse MGE explants in vitro
- section_id
- section_03
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- effect_size
- centrosome moves up to 30 µm ahead of the nucleus in the leading neurite
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-03-development
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- First, cytoplasmic organelles migrate forward, and second, the nucleus translocates toward these organelles.
- study_system
- mouse MGE explants in vitro
- section_title
- Developmental Origins and Postnatal Maturation
- evidence_summary
- Time-lapse imaging of MGE explants combined with pharmacological perturbation (blebbistatin) of nonmuscle myosin II.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-03-development
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
Nucleokinesis in tangentially migrating MGE interneurons proceeds in two alternating phases: forward translocation of the centrosome–Golgi swelling up to ~30 µm into the leading neurite, followed by myosin-II-dependent nuclear translocation toward the displaced organelles.
- raw_fields
{ "n": 0, "doi": "10.1523/jneurosci.1030-05.2005", "claim": "Nucleokinesis in tangentially migrating MGE interneurons proceeds in two alternating phases: forward translocation of the centrosome–Golgi swelling up to ~30 µm into the leading neurite, followed by myosin-II-dependent nuclear translocation toward the displaced organelles.", "title": null, "cite_key": "Bellion2005", "evidence": "Time-lapse imaging of MGE explants combined with pharmacological perturbation (blebbistatin) of nonmuscle myosin II.", "effect_size": "centrosome moves up to 30 µm ahead of the nucleus in the leading neurite", "text_access": "abstract_only", "study_system": "mouse MGE explants in vitro", "_source_cluster": "cluster_02_development_lineage", "replication_status": "replication_unknown", "_source_cluster_index": 43, "claim_source_sentence": "First, cytoplasmic organelles migrate forward, and second, the nucleus translocates toward these organelles.", "replication_evidence_dois": [], "effect_size_source_sentence": "the centrosome and the Golgi apparatus separates from the perinuclear compartment and moves rostrally into the leading neurite, up to 30 mum from the waiting nucleus." }- source_refs
[ "paper:paper-a6752795834f" ]
- evidence_refs
[ { "ref": "paper:paper-a6752795834f" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }