Anderson 2001: distinct cortical migrations from MGE vs LGE; MGE migrants enter…

Anderson 2001: distinct cortical migrations from MGE vs LGE; MGE migrants enter cortex tangentially while LGE-derived cells follow alternative routes including subpallial-to-pallial paths—classical foundation for GE-specific tangential migration that frames later CGE/LGE-CGE work.

{
  "n": null,
  "doi": "10.1242/dev.128.3.353",
  "year": "2001",
  "claim": "Anderson 2001: distinct cortical migrations from MGE vs LGE; MGE migrants enter cortex tangentially while LGE-derived cells follow alternative routes including subpallial-to-pallial paths—classical foundation for GE-specific tangential migration that frames later CGE/LGE-CGE work.",
  "title": "Distinct cortical migrations from the medial and lateral ganglionic eminences.",
  "authors": "Anderson SA, et al.",
  "journal": "Development (Cambridge, England)",
  "cite_key": "Anderson2001",
  "effect_size": null,
  "text_access": "abstract_only",
  "_source_cluster": "cluster_14_cge_lineage_context",
  "evidence_source": "abstract",
  "cluster_relevance": "cge_lineage_context",
  "fulltext_available": false,
  "replication_status": null,
  "_source_cluster_index": 34,
  "claim_source_sentence": "Recent evidence suggests that projection neurons and interneurons of the cerebral cortex are generally derived from distinct proliferative zones. Cortical projection neurons originate from the cortical ventricular zone (VZ), and then migrate radially into the cortical mantle, whereas most cortical interneurons originate from the basal telencephalon and migrate tangentially into the developing cortex. Previous studies using methods that label both proliferative and postmitotic cells have found that cortical interneurons migrate from two major subdivisions of the developing basal telencephalon: the medial and lateral ganglionic eminences (MGE and LGE). Since these studies labeled cells by methods that do not distinguish between the proliferating cells and those that may have originated elsewhere, we have studied the contribution of the MGE and LGE to cortical interneurons using fate mapping and genetic methods. Transplantation of BrdU-labeled MGE or LGE neuroepithelium into the basal telencephalon of unlabeled telencephalic slices enabled us to follow the fate of neurons derived from each of these primordia. We have determined that early in neurogenesis GABA-expressing cells from the"
}

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]

Recent evidence suggests that projection neurons and interneurons of the cerebral cortex are generally derived from distinct proliferative zones. Cortical projection neurons originate from the cortical ventricular zone (VZ), and then migrate radially into the cortical mantle, whereas most cortical interneurons originate from the basal telencephalon and migrate tangentially into the developing cortex. Previous studie...

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