Optogenetic stimulation of mediodorsal-thalamus axons in mouse anterior cingula…

Optogenetic stimulation of mediodorsal-thalamus axons in mouse anterior cingulate cortex evokes disynaptic feedforward inhibition mediated by parvalbumin (PV) interneurons that monosynaptically excite then inhibit L3 pyramidals; this feedforward-inhibition motif (analogous to sensory thalamocortical circuits) limits the time window for pyramidal-cell integration but allows greater temporal flexibility — circuit substrate for MD-PFC cognitive control and persistent-activity gating.

{
  "n": 0,
  "doi": "10.1523/jneurosci.4565-14.2015",
  "claim": "Optogenetic stimulation of mediodorsal-thalamus axons in mouse anterior cingulate cortex evokes disynaptic feedforward inhibition mediated by parvalbumin (PV) interneurons that monosynaptically excite then inhibit L3 pyramidals; this feedforward-inhibition motif (analogous to sensory thalamocortical circuits) limits the time window for pyramidal-cell integration but allows greater temporal flexibility — circuit substrate for MD-PFC cognitive control and persistent-activity gating.",
  "cite_key": "Delevich2015",
  "evidence": "This feedforward inhibition in the dACC limits the time window during which pyramidal neurons integrate excitatory synaptic inputs and fire action potentials, but in a manner that allows for greater flexibility than in sensory cortex.",
  "effect_size": "",
  "text_access": "abstract_only",
  "study_system": "mouse anterior cingulate cortex; channelrhodopsin-2 optogenetic stimulation of MD axons + whole-cell patch from L3 pyramidals and PV interneurons in acute slices",
  "argument_role": "supporting",
  "replication_status": "single_lab",
  "claim_source_sentence": "Axons arising from MD neurons directly synapse onto and excite PV interneurons that in turn mediate feedforward inhibition of pyramidal neurons in layer 3 of the dACC.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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