Yao et al. (2021) (BICCN epigenomic atlas) integrated seven scRNA-seq and snRNA…

Yao et al. (2021) (BICCN epigenomic atlas) integrated seven scRNA-seq and snRNA-seq datasets of mouse primary motor cortex (MOp) to establish a consensus transcriptomic reference atlas of 116 cell types, including replicable Vip subclasses across datasets and methods.

{
  "n": 500000,
  "doi": "10.1038/s41586-021-03500-8",
  "claim": "Yao et al. (2021) (BICCN epigenomic atlas) integrated seven scRNA-seq and snRNA-seq datasets of mouse primary motor cortex (MOp) to establish a consensus transcriptomic reference atlas of 116 cell types, including replicable Vip subclasses across datasets and methods.",
  "title": null,
  "cite_key": "Yao2021b",
  "evidence": "Joint clustering of 7 scRNA-seq/snRNA-seq datasets + epigenomic data on >500,000 mouse MOp cells; >56 replicable neuronal types including Vip subclasses; provides epigenomic regulatory elements concordant with transcriptomic VIP types.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "mouse MOp; integrated scRNA-seq + snRNA-seq + snmC-seq + snATAC-seq",
  "target_section": "section_02",
  "_source_cluster": "cluster_01_molecular_taxonomy",
  "replication_status": "replicated",
  "_source_cluster_index": 36,
  "claim_source_sentence": "Computational data integration jointly cluster and identify 116 cell types using all the datasets... resulting reference atlas — containing over 56 neuronal cell types that are highly replicable across analysis methods, sequencing technologies and modalities — is a comprehensive molecular and genomic account."
}

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Computational data integration jointly cluster and identify 116 cell types using all the datasets... resulting reference atlas — containing over 56 neuronal cell types that are highly replicable across analysis methods, sequencing technologies and modalities — is a comprehensive molecular and genomic account.

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