CGE-derived interneurons constitute ~30% of all cortical interneurons across ≥9…

CGE-derived interneurons constitute ~30% of all cortical interneurons across ≥9 distinct subtypes; CGE neurons preferentially populate superficial cortical layers (~75%) independent of birthdate, and most express either Reelin or VIP. CGE neurogenesis peaks at E16.5, ~3 days later than MGE.

{
  "n": null,
  "doi": "10.1523/jneurosci.4515-09.2010",
  "year": "2010",
  "claim": "CGE-derived interneurons constitute ~30% of all cortical interneurons across ≥9 distinct subtypes; CGE neurons preferentially populate superficial cortical layers (~75%) independent of birthdate, and most express either Reelin or VIP. CGE neurogenesis peaks at E16.5, ~3 days later than MGE.",
  "title": "Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons.",
  "authors": "Miyoshi G, et al.",
  "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience",
  "cite_key": "Miyoshi2010",
  "effect_size": null,
  "text_access": "abstract_only",
  "_source_cluster": "cluster_14_cge_lineage_context",
  "evidence_source": "abstract",
  "cluster_relevance": "cge_lineage_context",
  "fulltext_available": false,
  "replication_status": null,
  "_source_cluster_index": 0,
  "claim_source_sentence": "By combining an inducible genetic fate mapping strategy with electrophysiological analysis, we have systematically characterized the populations of cortical GABAergic interneurons that originate from the caudal ganglionic eminence (CGE). Interestingly, compared with medial ganglionic eminence (MGE)-derived cortical interneuron populations, the initiation [embryonic day 12.5 (E12.5)] and peak production (E16.5) of interneurons from this embryonic structure occurs 3 d later in development. Moreover, unlike either pyramidal cells or MGE-derived cortical interneurons, CGE-derived interneurons do not integrate into the cortex in an inside-out manner but preferentially (75%) occupy superficial cortical layers independent of birthdate. In contrast to previous estimates, CGE-derived interneurons are both considerably greater in number (approximately 30% of all cortical interneurons) and diversity (comprised by at least nine distinct subtypes). Furthermore, we found that a large proportion of CGE-derived interneurons, including the neurogliaform subtype, express the glycoprotein Reelin. In fact, most CGE-derived cortical interneurons express either Reelin or vasoactive intestinal polypeptid"
}

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  "paper:paper-2379d07993bd"
]

By combining an inducible genetic fate mapping strategy with electrophysiological analysis, we have systematically characterized the populations of cortical GABAergic interneurons that originate from the caudal ganglionic eminence (CGE). Interestingly, compared with medial ganglionic eminence (MGE)-derived cortical interneuron populations, the initiation [embryonic day 12.5 (E12.5)] and peak production (E16.5) of in...

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  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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