Integrative scRNA-seq of 685,692 interneurons from developing human and macaque…

Integrative scRNA-seq of 685,692 interneurons from developing human and macaque cerebral cortex + subcortex shows that within-ganglionic-eminence migration produces minimal transcriptomic alteration, whereas cortical tangential migration drives dramatic transcriptomic specification for destination and species divergence. Primate interneurons express CRH at late-fetal stages (vs postnatal emergence in mouse), and cell-type entropy increases progressively across human/macaque cortical development.

{
  "n": null,
  "doi": "10.1038/s41467-025-56058-8",
  "claim": "Integrative scRNA-seq of 685,692 interneurons from developing human and macaque cerebral cortex + subcortex shows that within-ganglionic-eminence migration produces minimal transcriptomic alteration, whereas cortical tangential migration drives dramatic transcriptomic specification for destination and species divergence. Primate interneurons express CRH at late-fetal stages (vs postnatal emergence in mouse), and cell-type entropy increases progressively across human/macaque cortical development.",
  "title": null,
  "cite_key": "Feng2025a",
  "evidence": "Nat Commun 2025. Method: cross-species (human vs macaque) integrative scRNA-seq of 685k INs from cortex+subcortex.",
  "effect_size": null,
  "figure_data": null,
  "text_access": "abstract_only",
  "key_entities": [
    "human",
    "macaque",
    "cross-species",
    "tangential migration",
    "CRH",
    "entropy",
    "ganglionic eminence",
    "scRNA-seq",
    "arealization",
    "temporal"
  ],
  "study_system": "developing human + macaque cerebral cortex + subcortex (685k interneurons)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "single_study",
  "_source_cluster_index": 148,
  "claim_source_sentence": "Our integrative and comparative analyses reveal that less transcriptomic alteration is accompanied by interneuron migration within the ganglionic eminence subdivisions, in contrast to the dramatic changes observed in cortical tangential migration, which mostly characterize the transcriptomic specification for different destinations and for species divergence. Moreover, the in-depth survey of temporal regulation illustrates species differences in the developmental dynamics of cell types, e.g., the employment of CRH in primate interneurons during late-fetal stage distinguishes from their postnatal emergence in mice.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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Our integrative and comparative analyses reveal that less transcriptomic alteration is accompanied by interneuron migration within the ganglionic eminence subdivisions, in contrast to the dramatic changes observed in cortical tangential migration, which mostly characterize the transcriptomic specification for different destinations and for species divergence. Moreover, the in-depth survey of temporal regulation illu...

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